Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors

被引：134

作者：

Lu, Yong ^{[1
,2
]}

Wang, Qiang ^{[2
]}

Xue, Gang ^{[1
]}

Bi, Enguang ^{[2
]}

Ma, Xingzhe ^{[2
]}

Wang, Aibo ^{[3
,4
]}

Qian, Jianfei ^{[2
]}

Dong, Chen ^{[3
,4
]}

Yi, Qing ^{[2
]}

机构：

[1] Wake Forest Sch Med, Dept Microbiol & Immunol, Winston Salem, NC 27101 USA

[2] Cleveland Clin, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA

[3] Tsinghua Univ, Inst Immunol, Beijing 100084, Peoples R China

[4] Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China

来源：

CANCER CELL | 2018年 / 33卷 / 06期

关键词：

ADOPTIVE IMMUNOTHERAPY; TRANSCRIPTION FACTOR; IN-VIVO; METASTATIC MELANOMA; IMMUNE HOMEOSTASIS; ANTITUMOR IMMUNITY; EFFECTOR; MEMORY; INFLAMMATION; ANTIGENS;

D O I：

10.1016/j.ccell.2018.05.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The antitumor effector T helper 1 (Th1) and Th17 cells represent two T cell paradigms: short-lived cytolytic Th1 cells and "stem cell-like'' memory Th17 cells. We report that Th9 cells represent a third paradigmthey are less-exhausted, fully cytolytic, and hyperproliferative. Only tumor-specific Th9 cells completely eradicated advanced tumors, maintained a mature effector cell signature with cytolytic activity as strong as Th1 cells, and persisted as long as Th17 cells in vivo. Th9 cells displayed a unique Pu. 1-Traf6-NF-kappa B activation-driven hyperproliferative feature, suggesting a persistence mechanism rather than an antiapoptotic strategy. Th9 antitumor efficacy depended on interleukin-9 and upregulated expression of Eomes and Traf6. Thus, tumor-specific Th9 cells are a more effective CD4(+) T cell subset for adoptive cancer therapy.

引用

页码：1048 / +

页数：20

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