Stereoselective synthesis of the phorboxazole A macrolide by ring-closing metathesis

被引：22

作者：

Wang, Bo ^{[1
]}

Forsyth, Craig J. ^{[1
]}

机构：

[1] Univ Minnesota, Inst Technol, Dept Chem, Minneapolis, MN 55455 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 23期

关键词：

D O I：

10.1021/ol0619922

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Described is a regio- and stereoselective ring-closing metathesis (RCM) to form the C2-C3 alkene of the macrolide-containing domain of phorboxazole A. This work demonstrates a dramatic effect of reaction solvent on RCM product (E/Z)-selectivity. This process offers an alternative assembly of the macrolide-containing domain of phorboxazole A, one of the most potent anticancer agents known.

引用

页码：5223 / 5226

页数：4

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