Gut hormones in the control of appetite

被引：87

作者：

Murphy, KG ^{[1
]}

Bloom, SR ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci & Technol, Fac Med, Dept Metab Med, London W12 ONN, England

来源：

EXPERIMENTAL PHYSIOLOGY | 2004年 / 89卷 / 05期

关键词：

D O I：

10.1113/expphysiol.2004.027789

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Obesity is one of the greatest threats to the health of the developed world. In order to design effective drugs to treat the alarming increase in obesity, it is essential to understand the physiology of normal appetite control and the pathophysiology of obesity. The hypothalamus interprets and integrates neural and humoral inputs to provide a coordinated feeding and energy expenditure response. Recent evidence suggests that certain gut hormones - ghrelin, polypeptide YY, pancreatic polypeptide, glucagon-like-peptide 1 and oxyntomodulin - have a physiological role in governing satiety via the hypothalamus. Gut hormone appetite-regulatory systems represent a potential target for the design of antiobesity drugs.

引用

页码：507 / 516

页数：10

共 102 条

[1] HUMAN DISTRIBUTION AND RELEASE OF A PUTATIVE NEW GUT HORMONE, PEPTIDE-YY [J].

ADRIAN, TE ;

FERRI, GL ;

BACARESEHAMILTON, AJ ;

FUESSL, HS ;

POLAK, JM ;

BLOOM, SR .

GASTROENTEROLOGY, 1985, 89 (05) :1070-1077

[2] Acute third ventricular administration of insulin decreases food intake in two paradigms [J].

Air, EL ;

Benoit, SC ;

Smith, KAB ;

Clegg, DJ ;

Woods, SC .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 72 (1-2) :423-429

[3] Characterization of the effects of pancreatic polypeptide in the regulation of energy balance [J].

Asakawa, A ;

Inui, A ;

Yuzuriha, H ;

Ueno, N ;

Katsuura, G ;

Fujimiya, M ;

Fujino, MA ;

Niijima, A ;

Meguid, MM ;

Kasuga, M .

GASTROENTEROLOGY, 2003, 124 (05) :1325-1336

[4] APPETITE-SUPPRESSANT ACTIVITY IN PLASMA OF RATS AFTER INTESTINAL-BYPASS SURGERY [J].

ATKINSON, RL ;

BRENT, EL .

AMERICAN JOURNAL OF PHYSIOLOGY, 1982, 243 (01) :R60-R64

[5] Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT [J].

Baldanzi, G ;

Filigheddu, N ;

Cutrupi, S ;

Catapano, F ;

Bonissoni, S ;

Fubini, A ;

Malan, D ;

Baj, G ;

Granata, R ;

Broglio, F ;

Papotti, M ;

Surico, N ;

Bussolino, F ;

Isgaard, J ;

Deghenghi, R ;

Sinigaglia, F ;

Prat, M ;

Muccioli, G ;

Ghigo, E ;

Graziani, A .

JOURNAL OF CELL BIOLOGY, 2002, 159 (06) :1029-1037

[6] Gut hormone PYY3-36 physiologically inhibits food intake [J].

Batterham, RL ;

Cowley, MA ;

Small, CJ ;

Herzog, H ;

Cohen, MA ;

Dakin, CL ;

Wren, AM ;

Brynes, AE ;

Low, MJ ;

Ghatei, MA ;

Cone, RD ;

Bloom, SR .

NATURE, 2002, 418 (6898) :650-654

[7] Inhibition of food intake in obese subjects by peptide YY3-36 [J].

Batterham, RL ;

Cohen, MA ;

Ellis, SM ;

Le Roux, CW ;

Withers, DJ ;

Frost, GS ;

Ghatei, MA ;

Bloom, SR .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (10) :941-948

[8] Pancreatic polypeptide reduces appetite and food intake in humans [J].

Batterham, RL ;

Le Roux, CW ;

Cohen, MA ;

Park, AJ ;

Ellis, SM ;

Patterson, M ;

Frost, GS ;

Ghatei, MA ;

Bloom, SR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (08) :3989-3992

[9] Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans [J].

Beglinger, C ;

Degen, L ;

Matzinger, D ;

D'Amato, M ;

Drewe, J .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (04) :R1149-R1154

[10]

Bourn J., 2001, TACKLING OBESITY ENG

← 1 2 3 4 5 6 7 8 9 10 →