Neutralizing antibody response against the B.1.617.2 (delta) and the B.1.1.529 (omicron) variants after a third mRNA SARS-CoV-2 vaccine dose in kidney transplant recipients

被引：40

作者：

Benning, Louise ^{[1
]}

Morath, Christian ^{[1
]}

Bartenschlager, Marie ^{[2
]}

Kim, Heeyoung ^{[2
]}

Reineke, Marvin ^{[1
]}

Beimler, Jorg ^{[1
]}

Buylaert, Mirabel ^{[1
]}

Nusshag, Christian ^{[1
]}

Kaelble, Florian ^{[1
]}

Reichel, Paula ^{[1
]}

Toellner, Maximilian ^{[1
]}

Schaier, Matthias ^{[1
]}

Klein, Katrin ^{[1
]}

Benes, Vladimir ^{[3
]}

Rausch, Tobias ^{[3
]}

Rieger, Susanne ^{[4
]}

Stich, Maximilian ^{[4
]}

Toenshoff, Burkhard ^{[4
]}

Weidner, Niklas ^{[5
]}

Schnitzler, Paul ^{[5
]}

Zeier, Martin ^{[1
]}

Susal, Caner ^{[6
,7
]}

Tran, Thuong Hien ^{[6
]}

Bartenschlager, Ralf ^{[2
,8
,9
]}

Speer, Claudius ^{[1
,10
]}

机构：

[1] Heidelberg Univ, Dept Nephrol, INF162, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Dept Infect Dis, Mol Virol, Heidelberg, Germany

[3] European Mol Biol Lab, Genom Core Facil, Heidelberg, Germany

[4] Univ Childrens Hosp Heidelberg, Dept Pediat 1, Heidelberg, Germany

[5] Heidelberg Univ, Dept Virol, Heidelberg, Germany

[6] Heidelberg Univ, Inst Immunol, Heidelberg, Germany

[7] Koc Univ Hosp, Transplant Immunol Res Ctr Excellence, Istanbul, Turkey

[8] German Ctr Infect Res, Heidelberg, Germany

[9] German Canc Res Ctr, Div Virus Associated Carcinogenesis, Heidelberg, Germany

[10] European Mol Biol Lab, Dept Mol Med Partnership Unit Heidelberg, Heidelberg, Germany

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2022年 / 22卷 / 07期

关键词：

clinical decision-making; clinical research; immune modulation; immunosuppression; kidney transplantation; nephrology; practice; solid organ transplantation; vaccine; BNT162B2;

D O I：

10.1111/ajt.17054

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Seroconversion after COVID-19 vaccination is impaired in kidney transplant recipients. Emerging variants of concern such as the B.1.617.2 (delta) and the B.1.1.529 (omicron) variants pose an increasing threat to these patients. In this observational cohort study, we measured anti-S1 IgG, surrogate neutralizing, and anti-receptor-binding domain antibodies three weeks after a third mRNA vaccine dose in 49 kidney transplant recipients and compared results to 25 age-matched healthy controls. In addition, vaccine-induced neutralization of SARS-CoV-2 wild-type, the B.1.617.2 (delta), and the B.1.1.529 (omicron) variants was assessed using a live-virus assay. After a third vaccine dose, anti-S1 IgG, surrogate neutralizing, and anti-receptor-binding domain antibodies were significantly lower in kidney transplant recipients compared to healthy controls. Only 29/49 (59%) sera of kidney transplant recipients contained neutralizing antibodies against the SARS-CoV-2 wild-type or the B.1.617.2 (delta) variant and neutralization titers were significantly reduced compared to healthy controls (p < 0.001). Vaccine-induced cross-neutralization of the B.1.1.529 (omicron) variants was detectable in 15/35 (43%) kidney transplant recipients with seropositivity for anti-S1 IgG, surrogate neutralizing, and/or anti-RBD antibodies. Neutralization of the B.1.1.529 (omicron) variants was significantly reduced compared to neutralization of SARS-CoV-2 wild-type or the B.1.617.2 (delta) variant for both, kidney transplant recipients and healthy controls (p < .001 for all).

引用

页码：1873 / 1883

页数：11

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