Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions

被引：214

作者：

Gao, Ming ^{[1
,2
]}

Li, Yi ^{[1
,2
]}

Xie, Lijuan ^{[1
,2
]}

Chauvinabc, Remi ^{[1
,2
,3
,4
]}

Cui, Xiuling ^{[1
,2
]}

机构：

[1] Huaqiao Univ, Engn Res Ctr Mol Med, Key Lab Xiamen Marine & Gene Drugs, Minist Educ,Inst Mol Med, Xiamen 361021, Peoples R China

[2] Huaqiao Univ, Sch Biomed Sci, Xiamen 361021, Peoples R China

[3] CNRS, Chim Coordinat Lab, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France

[4] Univ Toulouse, UPS, INPT, F-31077 Toulouse 4, France

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 13期

关键词：

DIALKYL H-PHOSPHONATES; CARBON-PHOSPHORUS FUNCTIONALIZATION; PALLADIUM-CATALYZED PHOSPHONATION; P BOND FORMATION; C-P; REGIOSELECTIVE PHOSPHONATION; PHOSPHINE OXIDES; ACIDS; ARYL; DIPHENYLPHOSPHINE;

D O I：

10.1039/c5cc08049e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A direct C-H bond phosphonation of quinoxalin-2(1H)-ones with H-phosphonates, H-phosphinates or H-phosphine oxides has been developed. A wide variety of heteroaryl phosphonates were obtained in up to 92% yield for 20 examples under transition-metal-free conditions. This protocol tolerates a broad scope of substrates and features practicality, high efficiency, environmental friendliness and atom economy.

引用

收藏

页码：2846 / 2849

页数：4

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