Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction

被引：32

作者：

Chen, Zhi-Peng ^{[1
]}

Wang, Hai-Bo ^{[1
]}

Wang, Yu-Qin ^{[1
]}

Zhu, Qiu-Hua ^{[1
]}

Xie, Yang ^{[1
]}

Liu, Shu-Wen ^{[1
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

来源：

TETRAHEDRON | 2014年 / 70卷 / 29期

关键词：

Multicomponent reaction; Proline; Pyrrolo[3,4-d]tetrahydropyrimidine; Synthesis; POTENTIAL INHIBITORS; KINASE INHIBITORS; DOMINO REACTIONS; TETRAHYDROPYRIMIDINES; DESIGN; CYCLOADDITION; HETEROCYCLES; RECEPTOR;

D O I：

10.1016/j.tet.2014.04.075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Novel proline-catalyzed multicomponent reactions (MCRs) for the synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidines 7 and 9 with different substituted patterns have been developed, which provide rapid access to a library of compounds 7 and 9 in medium to excellent yields, by using N-methyl-alpha-aryl(alkyl)aminomaleimides, amines, and aldehydes as reactants. The catalyst and the ratio of reactants were found to have significant impact on these reactions, and a reasonable mechanism was also proposed. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4379 / 4385

页数：7

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