New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa.: Part 2:: Synthesis and structure-activity relationships in the S-3578 series

被引：12
|
作者：
Yoshizawa, H [1 ]
Kubota, T [1 ]
Itani, H [1 ]
Ishitobi, H [1 ]
Miwa, H [1 ]
Nishitani, Y [1 ]
机构：
[1] Shionogi & Co Ltd, Shionogi Res Labs, Fukushima Ku, Osaka 5530002, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 15期
关键词：
D O I：
10.1016/j.bmc.2004.05.022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Among the prepared novel cephalosporin derivatives related to S-3578, a series of 7beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2(Z) -ethoxyiminoacetamido]-3-[1-(aminoalkyl)-1H-pyrazoIo[4,3-b]pyridinium-4-yl]methyl-3-cephem-4-carboxylate showed potent activity against both MRSA and Pseudomonas aeruginosa, and displayed good water solubility. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4211 / 4219
页数：9
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