Macromolecular cell surface engineering for accelerated and reversible cellular aggregation

被引:16
作者
Amaral, Aderito J. R. [1 ]
Pasparakis, George [1 ]
机构
[1] UCL, UCL Sch Pharm, London WC1N 1AX, England
关键词
MULTILAYER THIN-FILMS; POLYMER-SOLUTIONS; HYDROGELS; DELIVERY; CULTURE; TISSUE; DNA;
D O I
10.1039/c5cc07001e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report the synthesis of two simple copolymers that induce rapid cell aggregation within minutes in a fully reversible manner. The polymers can act as self-supporting "cellular glues'' or as "drivers'' of 3D cell spheroids/aggregates formation at minute concentrations.
引用
收藏
页码:17556 / 17559
页数:4
相关论文
共 41 条
  • [1] Enzymatically degradable poly(ethylene glycol) hydrogels for the 3D culture and release of human embryonic stem cell derived pancreatic precursor cell aggregates
    Amer, Luke D.
    Holtzinger, Audrey
    Keller, Gordon
    Mahoney, Melissa J.
    Bryant, Stephanie J.
    [J]. ACTA BIOMATERIALIA, 2015, 22 : 103 - 110
  • [2] Emerging synthetic approaches for protein-polymer conjugations
    Broyer, Rebecca M.
    Grover, Gregory N.
    Maynard, Heather D.
    [J]. CHEMICAL COMMUNICATIONS, 2011, 47 (08) : 2212 - 2226
  • [3] Polypeptide-polymer bioconjugates
    Canalle, Luiz A.
    Lowik, Dennis W. P. M.
    van Hest, Jan C. M.
    [J]. CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) : 329 - 353
  • [4] Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery
    Cheng, Hao
    Kastrup, Christian J.
    Ramanathan, Renuka
    Siegwart, Daniel J.
    Ma, Minglin
    Bogatyrev, Said R.
    Xu, Qiaobing
    Whitehead, Kathryn A.
    Langer, Robert
    Anderson, Daniel G.
    [J]. ACS NANO, 2010, 4 (02) : 625 - 631
  • [5] Multicellular aggregation of maltol-modified cells triggered by Fe3+ ions
    Ciupa, Alexander
    De Bank, Paul A.
    Caggiano, Lorenzo
    [J]. CHEMICAL COMMUNICATIONS, 2013, 49 (86) : 10148 - 10150
  • [6] Accelerated formation of multicellular 3-D structures by cell-to-cell cross-linking
    De Bank, Paul A.
    Hou, Qingpu
    Warner, Robert M.
    Wood, Ian V.
    Ali, Bahaa E.
    MacNeil, Sheila
    Kendall, David A.
    Kellam, Barrie
    Shakesheff, Kevin M.
    Buttery, Lee D. K.
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2007, 97 (06) : 1617 - 1625
  • [7] A Direct Technique for Magnetic Functionalization of Living Human Cells
    Dzamukova, Maria R.
    Zamaleeva, Alsu I.
    Ishmuchametova, Dilara G.
    Osin, Yuri N.
    Kiyasov, Andrey P.
    Nurgaliev, Danis K.
    Ilinskaya, Olga N.
    Fakhrullin, Rawil F.
    [J]. LANGMUIR, 2011, 27 (23) : 14386 - 14393
  • [8] Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
    Gartner, Zev J.
    Bertozzi, Carolyn R.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (12) : 4606 - 4610
  • [9] Peptide/protein-polymer conjugates: synthetic strategies and design concepts
    Gauthier, Marc A.
    Klok, Harm-Anton
    [J]. CHEMICAL COMMUNICATIONS, 2008, (23) : 2591 - 2611
  • [10] Cell adhesion: The molecular basis of tissue architecture and morphogenesis
    Gumbiner, BM
    [J]. CELL, 1996, 84 (03) : 345 - 357