Macromolecular cell surface engineering for accelerated and reversible cellular aggregation

被引：17
作者：
Amaral, Aderito J. R. [1 ]
Pasparakis, George [1 ]
机构：
[1] UCL, UCL Sch Pharm, London WC1N 1AX, England
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 99期
关键词：
MULTILAYER THIN-FILMS; POLYMER-SOLUTIONS; HYDROGELS; DELIVERY; CULTURE; TISSUE; DNA;
D O I：
10.1039/c5cc07001e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the synthesis of two simple copolymers that induce rapid cell aggregation within minutes in a fully reversible manner. The polymers can act as self-supporting "cellular glues'' or as "drivers'' of 3D cell spheroids/aggregates formation at minute concentrations.
引用
收藏
页码：17556 / 17559
页数：4
相关论文
共 41 条
[1]   Enzymatically degradable poly(ethylene glycol) hydrogels for the 3D culture and release of human embryonic stem cell derived pancreatic precursor cell aggregates [J].
Amer, Luke D. ;
Holtzinger, Audrey ;
Keller, Gordon ;
Mahoney, Melissa J. ;
Bryant, Stephanie J. .
ACTA BIOMATERIALIA, 2015, 22 :103-110
[2]   Emerging synthetic approaches for protein-polymer conjugations [J].
Broyer, Rebecca M. ;
Grover, Gregory N. ;
Maynard, Heather D. .
CHEMICAL COMMUNICATIONS, 2011, 47 (08) :2212-2226
[3]   Polypeptide-polymer bioconjugates [J].
Canalle, Luiz A. ;
Lowik, Dennis W. P. M. ;
van Hest, Jan C. M. .
CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) :329-353
[4]   Nanoparticulate Cellular Patches for Cell-Mediated Tumoritropic Delivery [J].
Cheng, Hao ;
Kastrup, Christian J. ;
Ramanathan, Renuka ;
Siegwart, Daniel J. ;
Ma, Minglin ;
Bogatyrev, Said R. ;
Xu, Qiaobing ;
Whitehead, Kathryn A. ;
Langer, Robert ;
Anderson, Daniel G. .
ACS NANO, 2010, 4 (02) :625-631
[5]   Multicellular aggregation of maltol-modified cells triggered by Fe3+ ions [J].
Ciupa, Alexander ;
De Bank, Paul A. ;
Caggiano, Lorenzo .
CHEMICAL COMMUNICATIONS, 2013, 49 (86) :10148-10150
[6]   Accelerated formation of multicellular 3-D structures by cell-to-cell cross-linking [J].
De Bank, Paul A. ;
Hou, Qingpu ;
Warner, Robert M. ;
Wood, Ian V. ;
Ali, Bahaa E. ;
MacNeil, Sheila ;
Kendall, David A. ;
Kellam, Barrie ;
Shakesheff, Kevin M. ;
Buttery, Lee D. K. .
BIOTECHNOLOGY AND BIOENGINEERING, 2007, 97 (06) :1617-1625
[7]   A Direct Technique for Magnetic Functionalization of Living Human Cells [J].
Dzamukova, Maria R. ;
Zamaleeva, Alsu I. ;
Ishmuchametova, Dilara G. ;
Osin, Yuri N. ;
Kiyasov, Andrey P. ;
Nurgaliev, Danis K. ;
Ilinskaya, Olga N. ;
Fakhrullin, Rawil F. .
LANGMUIR, 2011, 27 (23) :14386-14393
[8]   Programmed assembly of 3-dimensional microtissues with defined cellular connectivity [J].
Gartner, Zev J. ;
Bertozzi, Carolyn R. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (12) :4606-4610
[9]   Peptide/protein-polymer conjugates: synthetic strategies and design concepts [J].
Gauthier, Marc A. ;
Klok, Harm-Anton .
CHEMICAL COMMUNICATIONS, 2008, (23) :2591-2611
[10]   Cell adhesion: The molecular basis of tissue architecture and morphogenesis [J].
Gumbiner, BM .
CELL, 1996, 84 (03) :345-357
12345