Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer

被引:3
作者
Ren, Ying-Kun [1 ]
Xiao, Yan [2 ]
Wan, Xiang-Bin [1 ]
Zhao, Yu-Zhou [1 ]
Li, Jian [1 ]
Li, Yin [3 ]
Han, Guang-Sen [1 ]
Chen, Xiao-Bing [4 ]
Zou, Qi-Yun [1 ]
Wang, Gang-Cheng [1 ]
Lu, Chao-Min [1 ]
Xu, Yong-Chao [1 ]
Wang, You-Cai [1 ]
机构
[1] Zhengzhou Univ, Affiliated Canc Hosp, Dept Gen Surg, Zhengzhou 450008, Peoples R China
[2] Zhengzhou Univ, Affiliated Canc Hosp, Dept Gynecol Oncol, Zhengzhou 450008, Peoples R China
[3] Zhengzhou Univ, Affiliated Canc Hosp, Dept Thorac Surg, Zhengzhou 450008, Peoples R China
[4] Zhengzhou Univ, Affiliated Canc Hosp, Dept Oncol, Zhengzhou 450008, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 09期
关键词
lncRNA; HOTTIP; colorectal cancer; prognosis; EXPRESSION; CARCINOMA; CHROMATIN; PATHWAYS; COLON;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Long non-coding RNA (lncRNA) has an important role in carcinoma progression and prognosis. However, little is known about the pathological role of lncRNA HOTTIP (HOXA transcript at the distal tip) in colorectal cancer (CRC) patients. This study attempted to investigate the association of lncRNA HOTTIP expression with progression and prognosis in CRC patients. LncRNA HOTTIP expression was measured in 156 CRC tissues and 21 adjacent non-malignant tissues using qRT-PCR. In present study, our results indicated that lncRNA HOTTIP was highly expressed in CRC compared with adjacent non-malignant tissues (P<0.001), and positively correlated with T stage (T1-2 vs. T3-4, P = 0.001), clinical stage (I-II stages vs. III-IV stages, P = 0.003), and distant metastasis (absent vs. present, P = 0.014) in CRC patients. Furthermore, we also observed that increased lncRNA HOTTIP expression was an unfavorable prognostic factor in CRC patients (P = 0.001), regardless of T stage, distant metastasis and clinical stage. Finally, overexpression of lncRNA HOTTIP was supposed to be an independent poor prognostic factor for CRC patients through multivariate analysis (P = 0.017). In conclusion, lncRNA HOTTIP overexpression maybe serves as an unfavorable prognosis predictor for CRC patients. However, a further larger sample size investigation is needed to support our results.
引用
收藏
页码:11458 / 11463
页数:6
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