Alternative pre-mRNA splicing and proteome expansion in metazoans

被引：598
|
作者：
Maniatis, T [1 ]
Tasic, B [1 ]
机构：
[1] Harvard Univ, Dept Cellular & Mol Biol, Cambridge, MA 02138 USA
来源：
NATURE | 2002年 / 418卷 / 6894期
关键词：
D O I：
10.1038/418236a
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The protein coding sequences of most eukaryotic messenger RNA precursors (pre mRNAs) are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process by which introns are removed and the protein coding elements assembled into mature mRNAs. Alternative pre-mRNA splicing selectively joins different protein coding elements to form mRNAs that encode proteins with distinct functions, and is therefore an important source of protein diversity. The elaboration of this mechanism may have had a significant role in the expansion of metazoan proteomes during evolution.
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收藏
页码：236 / 243
页数：8
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