Synthesis and characterization of amphiphilic block polymer poly(ethylene glycol)-poly(propylene carbonate)-poly(ethylene glycol) for drug delivery

被引：23
|
作者：
Li, Hongchun [1 ]
Niu, Yongsheng [1 ]
机构：
[1] Qingdao Agr Univ, Coll Chem & Pharm, Qingdao 266109, Peoples R China
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2018年 / 89卷
基金：
美国国家科学基金会;
关键词：
Amphiphilic block polymer; Poly(propylene carbonate); Condensation reaction; Poly(ethylene glycol); Drug delivery; MICELLES; COPOLYMERS; DESIGN; NANOPARTICLES; NANOCARRIERS; HYDROGELS; CARRIERS; RELEASE; SYSTEMS;
D O I：
10.1016/j.msec.2018.04.002
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
A novel amphiphilic block polymer poly(ethylene glycol)-poly(propylene carbonate)-poly(ethylene glycol) (PEG-PPC-PEG) was synthesized via the dicyclohexylcarbodiimide condensation reaction of double PEG-bis-amine and HOOC-PPC-COOH. The obtained copolymer was characterized by NMR to determine its structure. Using the PEG-PPC-PEG as the carrier and using doxorubicin (DOX) as a model drug, DOX-loaded nanoparticles with core shell structure were synthesized by self-assembly in water. The nanoparticles properties such as particle size, drug loading, encapsulation efficiency (EE) and drug release behavior were investigated as a function of the hydrophobic block length of PPC segments and compared with each other. The results showed that the EE was up to 88.8%. Nanoparticles were found to have a certain effect on the controlled release of DOX.
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页码：160 / 165
页数：6
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