Solubility and thermodynamic parameters of a novel anti-cancer drug (DHP-5) in polyethylene glycol 400+water mixtures

被引：39

作者：

Shakeel, Faiyaz ^{[1
]}

Bhat, Mashooq A. ^{[2
]}

Haq, Nazrul ^{[1
]}

Fathi-Azarbayjani, Anahita ^{[3
,4
]}

Jouyban, Abolghasem ^{[5
,6
,7
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmaceut, POB 2457, Riyadh 11451, Saudi Arabia

[2] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, POB 2457, Riyadh 11451, Saudi Arabia

[3] Urmia Univ Med Sci, Dept Pharmaceut, Sch Pharm, Orumiyeh, Iran

[4] Urmia Univ Med Sci, Solid Tumor Res Ctr, Orumiyeh, Iran

[5] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz 51664, Iran

[6] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

[7] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan KIPA Sci Based Co, Tabriz 51664, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2017年 / 229卷

关键词：

Solubility; DHP-5; Solvent mixture; Jouyban-Acree model; van't Hoff equation; WATER COSOLVENT MIXTURES; N-METHYL-PYRROLIDONE; K EXPERIMENTAL-DATA; PROPYLENE-GLYCOL; TERNARY SOLVENTS; AQUEOUS MIXTURES; JOUYBAN-ACREE; PLUS ETHANOL; BINARY-MIXTURES; PEGS; 200;

D O I：

10.1016/j.molliq.2016.12.067

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Solubility of dihydropyrimidine derivative 4-(4-ethoxyphenyl)-5-(3,4,5 trimethoxybenzoyI)-3,4dihydropyrimidine-2(1H) one (DHP-5), a novel anticancer drug, was experimentally measured in PEG 400 + water binary solvent mixtures over a temperatures range from 298.15 to 318.15 K. Thermodynamic parameters including enthalpy, entropy and Gibbs free energy of the solubility data were calculated using van't Hoff equation. Experimental solubility data was employed to evaluate the relative performance of a number of models including van't Hoff, Apelblat, Yalkowsky and Jouyba-Acree models for their prediction efficacy. The Jouyban-Acree model covering both solvent composition and temperature effects on drug's solubility proved to be superior to the other three models for its prediction accuracy. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：241 / 245

页数：5

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