Novel Prognostic Factor for Uveal Melanoma: Bioinformatics Analysis of Three Independent Cohorts

被引：11

作者：

Choi, Suji ^{[1
]}

Ha, Mihyang ^{[1
]}

Lee, Jung Sub ^{[2
,3
]}

Heo, Hye Jin ^{[4
]}

Kim, Ga Hyun ^{[4
]}

Oh, Sae-Ock ^{[4
]}

Lee, Jae Jung ^{[3
,5
]}

Goh, Tae Sik ^{[2
,3
]}

Kim, Yun Hak ^{[4
,6
]}

机构：

[1] Pusan Natl Univ, Interdisciplinary Program Genom Data Sci, Yangsan, South Korea

[2] Pusan Natl Univ Hosp, Dept Orthopaed Surg, Busan 49241, South Korea

[3] Pusan Natl Univ Hosp, Biomed Res Inst, Busan 49241, South Korea

[4] Pusan Natl Univ, Sch Med, Dept Anat, Yangsan, South Korea

[5] Pusan Natl Univ Hosp, Dept Ophthalmol, Busan, South Korea

[6] Pusan Natl Univ, Dept Biomed Informat, Yangsan 50612, South Korea

来源：

ANTICANCER RESEARCH | 2020年 / 40卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Uveal melanoma; The Cancer Genome Atlas; Gene Expression Omnibus; prognosis; bioinformatics; GENE-EXPRESSION; CANCER;

D O I：

10.21873/anticanres.14373

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Because 50% of uveal melanoma metastasize within 10 years of diagnosis, there is urgent need for accurate prognostic factors. Materials and Methods: To identify genes that can act as prognostic factors in uveal melanoma, we performed survival analyses using three independent cohorts. Using log- rank test and univariate cox regression, genes which could stratify the prognosis in all cohorts simultaneously depending on their expression levels were selected as novel biomarkers. Hub genes were obtained by analyzing the interaction and relationship between the selected genes using String and Cytoscape. Additionally, prognostic power was calculated by using C-indices and AUC. Results: A total of 37 oncogenelike and 14 tumor suppressor- like genes were selected. Protein-protein analysis revealed that NDUFB9, NDUFV2, CYC1 among oncogene-like genes, CTNNB1 among tumor suppressor-like genes were found to be hub genes and core biomarkers in uveal melanoma. Conclusion: NDUFB9, NDUFV2, CYC1 and CTNNB1 genes may act as prognostic factors in uveal melanoma.

引用

页码：3839 / 3846

页数：8

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