CRYSTAL STRUCTURE OF CYP2B6 IN COMPLEX WITH AN EFAVIRENZ ANALOG: FROM PLASTICITY TO PI INTERACTIONS IN CYP2B ENZYMES

被引:0
|
作者
Shah, Manish B. [1 ,2 ]
Halpert, James R. [1 ]
机构
[1] Univ Connecticut, Sch Pharm, Storrs, CT USA
[2] Albany Coll Pharm & Hlth Sci, Albany, NY USA
关键词
D O I
10.1016/j.dmpk.2017.11.122
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
P35
引用
收藏
页码:S32 / S33
页数:5
相关论文
共 50 条
  • [1] Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog
    Shah, Manish B.
    Zhang, Qinghai
    Halpert, James R.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (04)
  • [2] CYP2B6 GENETIC VARIATION AND EFAVIRENZ AUTOINDUCTION INFLUENCES CYP2B6 A ACTIVITY AND EFAVIRENZ EXPOSURE IN HEALTHY VOLUNTEERS
    Metzger, I. F.
    Lu, J. B.
    Kreutz, Y.
    Thong, N.
    Flockhart, D. A.
    Desta, Z.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 93 : S80 - S80
  • [3] Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure:: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4
    Lewis, DFV
    Lake, BG
    Dickins, M
    Eddershaw, PJ
    Tarbit, MH
    Goldfarb, PS
    XENOBIOTICA, 1999, 29 (04) : 361 - 393
  • [5] Effects of the CYP2B6*6 Allele on Catalytic Properties and Inhibition of CYP2B6 In Vitro: Implication for the Mechanism of Reduced Efavirenz Metabolism and Other CYP2B6 Substrates In Vivo
    Xu, Cong
    Ogburn, Evan T.
    Guo, Yingying
    Desta, Zeruesenay
    DRUG METABOLISM AND DISPOSITION, 2012, 40 (04) : 717 - 725
  • [6] Plasticity of CYP2B Enzymes: Structural and Solution Biophysical Methods
    Wilderman, P. Ross
    Halpert, James R.
    CURRENT DRUG METABOLISM, 2012, 13 (02) : 167 - 176
  • [7] Efavirenz intoxication due to a new CYP2B6 constellation
    Anagnostopoulos, Alexia
    Rotger, Margalida
    Aouri, Manel
    Kuster, Stefan P.
    Telenti, Amalio
    Decosterd, Laurent A.
    Guenthard, Huldrych F.
    ANTIVIRAL THERAPY, 2013, 18 (05) : 739 - 743
  • [8] CYP2B6 poor metaboliser alleles involved in efavirenz and nevirapine metabolism: CYP2B6*9 and CYP2B6*18 distribution in HIV-exposed subjects from Dschang, Western Cameroon
    Paganotti, Giacomo Maria
    Russo, Gianluca
    Sobze, Martin Sanou
    Mayaka, George Bouting
    Muthoga, Charles Waithaka
    Tawe, Leabaneng
    Martinelli, Axel
    Romano, Rita
    Vullo, Vincenzo
    INFECTION GENETICS AND EVOLUTION, 2015, 35 : 122 - 126
  • [9] Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry
    Wang, Pan-Fen
    Neiner, Alicia
    Kharasch, Evan D.
    DRUG METABOLISM AND DISPOSITION, 2019, 47 (10) : 1195 - 1205
  • [10] Novel CYP2B6 polymorphisms and their impact on efavirenz and bupropion metabolism
    Klein, K.
    Radloff, R.
    Gras, A.
    Masquelier, C.
    Arumugam, K.
    Karasi, J-C
    Seguin-Devaux, C.
    Zanger, U. M.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2013, 386 : S41 - S41