The synthesis of a new probe for PET imaging reporter gene HSV1-tk:: 2-amino-6-[18F] fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[18F]fluoropenciclovir)

被引：6

作者：

Cai, Hancheng

Yin, Duanzhi

Zhang, Lan

Wang, Yongxian

机构：

[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Res Ctr Radiopharmaceut, Shanghai 201800, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2006年 / 49卷 / 07期

关键词：

fluorine-18; synthesis; penciclovir; radiofluorination;

D O I：

10.1002/jlcr.1080

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The one step radiosynthesis of 2-amino-6-[F-18]fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[F-18]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[F-18]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [F-18]KF and isolated by a silica Sep-Pak cartridge. The radiochemical yield of compound 6 was 45-55% decay corrected (d.c.) in six runs with radiochemical purity > 98% and the radiosynthesis time was 35-42 min from end of bombardment (EOB). Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：653 / 661

页数：9