The synthesis of a new probe for PET imaging reporter gene HSV1-tk:: 2-amino-6-[18F] fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[18F]fluoropenciclovir)

被引：6
|
作者：
Cai, Hancheng
Yin, Duanzhi
Zhang, Lan
Wang, Yongxian
机构：
[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Res Ctr Radiopharmaceut, Shanghai 201800, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2006年 / 49卷 / 07期
关键词：
fluorine-18; synthesis; penciclovir; radiofluorination;
D O I：
10.1002/jlcr.1080
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The one step radiosynthesis of 2-amino-6-[F-18]fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-[F-18]fluoropenciclovir) 6 is reported. Radiolabeled product 6-[F-18]fluoropenciclovir 6 was prepared by radiofluorination of compound 4 with [F-18]KF and isolated by a silica Sep-Pak cartridge. The radiochemical yield of compound 6 was 45-55% decay corrected (d.c.) in six runs with radiochemical purity > 98% and the radiosynthesis time was 35-42 min from end of bombardment (EOB). Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码：653 / 661
页数：9
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