Assembly into β-Sheet Structures upon Peptide-Liposome Conjugation through Copper(I)-Catalyzed [3+2] Azide-Alkyne Cycloaddition

被引：2

作者：

Cavalli, Silvia ^{[1
]}

Overhand, Mark ^{[2
]}

Kros, Alexander ^{[2
]}

机构：

[1] Ist Italiano Tecnol, Ctr Adv Biomat Hlth Care IIT CRIB, I-80125 Naples, Italy

[2] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

CHEMPLUSCHEM | 2014年 / 79卷 / 04期

关键词：

circular dichroism; click chemistry; liposomes; peptides; self-assembly; DIAZO TRANSFER; NANOSTRUCTURES; MINERALIZATION; NANOPARTICLES;

D O I：

10.1002/cplu.201300354

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The random-coil-to--sheet transition of the (Leu-Glu)(4) peptide motif is induced upon its conjugation to the liposome surface through click chemistry. Circular dichroism (CD) spectroscopy enables the insitu monitoring of this reaction. A change in the peptide secondary structure is already observed within 15min. The -sheet conformation becomes the dominant secondary structure after 45min, as shown by the strong CD signal observed, which is typical for a -sheet peptide secondary structure.

引用

页码：564 / 568

页数：5

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