Nickel nanoparticle-catalyzed facile and efficient one-pot synthesis of polyhydroquinoline derivatives via Hantzsch condensation under solvent-free conditions

被引：262

作者：

Sapkal, Suryakant B. ^{[1
]}

Shelke, Kiran F. ^{[1
]}

Shingate, Bapurao B. ^{[1
]}

Shingare, Murlidhar S. ^{[1
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 15期

关键词：

Nanoparticle; Polyhydroquinoline derivative; Hantzsch condensation; Green chemistry; HYDROGEN-TRANSFER REDUCTION; MULTICOMPONENT REACTION; 1,4-DIHYDROPYRIDINES; CLAY;

D O I：

10.1016/j.tetlet.2009.01.140

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polyhydroquinoline derivatives have been prepared efficiently in a one-pot synthesis via Hantzsch condensation using nanosized Nickel (Ni) as a heterogeneous catalyst. The present method does not involve any hazardous organic solvents or catalysts. The smaller size of Ni (80 +/- 0.5 nm) having a higher surface to volume ratio has promising features for the reaction response such as the shortest reaction time, excellent product yields, simple work-up procedure, and purification of products by non-chromatographic methods. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1754 / 1756

页数：3

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