Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice

被引：21

作者：

Mahesh, Bandari Uma ^{[3
]}

Shrivastava, Shweta ^{[1
]}

Kuncha, Madhusudhana ^{[2
]}

Sahu, Bidya Dhar ^{[2
]}

Swamy, Challa Veerabhadra ^{[1
]}

Pragada, Rajeswara Rao ^{[3
]}

Naidu, V. G. M. ^{[1
]}

Sistla, Ramakrishna ^{[1
,2
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res NIPER Hyderabad, Dept Pharmacol & Toxicol, Hyderabad 500037, Andhra Pradesh, India

[2] Indian Inst Chem Technol, Div Pharmacol, Hyderabad 500007, Andhra Pradesh, India

[3] Andhra Univ, Dept Pharmacol, AU Coll Pharmaceut Sci, Visakhapatnam 530003, Andhra Pradesh, India

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2013年 / 36卷 / 03期

关键词：

Antioxidant; Cardioprotective; Doxorubicin; Boswellia malifoliolata; ANTIOXIDANT; PREVENTION;

D O I：

10.1016/j.etap.2013.07.016

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The aim of the study was to investigate the potential protective effect of ethanolic extract of Boswellia ovalifoliolata (BO) bark and leaf against doxorubicin (DOX)-induced cardiotoxicity in mice. Ethanolic extracts of BO bark (400 mg/kg) and leaves (250 mg/kg) were given orally to mice for 9 consecutive days and DOX (15 mg/kg; i.p.) was administered on the seventh day. Extract protected against DOX-induced ECG changes. It significantly inhibited DOX-provoked glutathione depletion and accumulation of malondialdehyde. The decrease in antioxidant enzyme activities of catalase, superoxide dismutase, glutathione peroxidase in cardiac tissue were significantly (p<0.05) mitigated after treatment with BO bark and leaf extracts. Pretreatment with BO significantly (p<0.05) restored the levels of DOX-induced rise of SGPT, SGOT, serum lactate dehydrogenase and creatine kinase-MB levels. These findings suggest that ethanolic extract of BO has protective effects against DOX-induced cardiotoxicity. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：840 / 849

页数：10