Neurologic Disorders in Immunocompetent Patients with Autochthonous Acute Hepatitis E

被引：57

作者：

Perrin, H. Blasco ^{[1
]}

Cintas, P. ^{[1
]}

Abravanel, F. ^{[1
]}

Gerolami, R. ^{[2
]}

d'Alteroche, L. ^{[3
]}

Raynal, J. -N. ^{[4
]}

Alric, L. ^{[1
]}

Dupuis, E. ^{[5
]}

Prudhomme, L. ^{[6
]}

Vaucher, E. ^{[7
]}

Couzigou, R. ^{[8
]}

Liversain, J. -M. ^{[9
]}

Bureau, C. ^{[1
]}

Vinel, J. -P. ^{[1
]}

Kamar, N. ^{[10
]}

Izopet, J. ^{[1
]}

Peron, J. -M. ^{[1
]}

机构：

[1] CHU Toulouse, Hop Purpan, Toulouse, France

[2] CHU Marseille, Hop La Concept, Marseille, France

[3] CHU Tours, Hop Trousseau, Tours, France

[4] Clin LUnion, Lunion, France

[5] Clin Pasteur, Toulouse, France

[6] CHIC Castres Mazamet, Castres, France

[7] CH Narbonne, Narbonne, France

[8] CHU Bordeaux, Hop Haut Leveque, Bordeaux, France

[9] CH Mont De Marsan, Mont De Marsan, France

[10] CHU Toulouse, Hop Ranguei, Toulouse, France

来源：

EMERGING INFECTIOUS DISEASES | 2015年 / 21卷 / 11期

关键词：

E VIRUS; RIBAVIRIN TREATMENT; LIVER-FAILURE; FRANCE; MANIFESTATIONS; THERAPY;

D O I：

10.3201/eid2111.141789

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neurologic disorders, mainly Guillain-Barre syndrome and Parsonage Turner syndrome (PTS), have been described in patients with hepatitis E virus (HEV) infection in industrialized and developing countries. We report a wider range of neurologic disorders in nonimmunocompromised patients with acute HEV infection. Data from 15 French immunocompetent patients with acute HEV infection and neurologic disorders were retrospectively recorded from January 2006 through June 2013. The disorders could be divided into 4 main entities: mononeuritis multiplex, PTS, nneningoradic-ulitis, and acute demyelinating neuropathy. HEV infection was treated with ribavirin in 3 patients (for PTS or mononeuritis multiplex). One patient was treated with corticosteroids (for mononeuropathy multiplex), and 5 others received intravenous immunoglobulin (for PTS, meningoradiculitis, Guillain-Barre syndrome, or Miller Fisher syndrome). We conclude that pleiotropic neurologic disorders are seen in HEV-infected immunocompetent patients. Patients with acute neurologic manifestations and aminotransferase abnormalities should be screened for HEV infection.

引用

页码：1928 / 1934

页数：7

共 24 条

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