In-vitro activity of tigecycline against clinical isolates of Acinetobacter baumannii in Taiwan

被引：16

作者：

Liu, Jien-Wei ^{[2
]}

Wang, Lih-Shinn ^{[3
]}

Cheng, Yu-Jen ^{[4
]}

Hsu, Gwo-Jong ^{[5
]}

Lu, Po-Liang ^{[6
]}

Liu, Yung-Ching ^{[7
]}

Chen, Chih-Ming ^{[8
]}

Lee, Chun-Ming ^{[9
]}

Sun, Wu ^{[10
]}

Jang, Tsrang-Neng ^{[11
]}

Chiang, Ping-Cherng ^{[12
]}

Chuang, Yin-Ching ^{[13
]}

Lin, Hsiu-Chen ^{[14
]}

Shi, Zhi-Yuan ^{[15
]}

Kung, Hsiang-Chi ^{[16
]}

Huang, Cheng-Hua ^{[1
]}

Tsao, Shih-Ming ^{[17
]}

Lu, Chin-Te ^{[18
]}

Liao, Chun-Hsing ^{[19
]}

Hsueh, Po-Ren ^{[20
,21
]}

机构：

[1] Cathay Gen Hosp, Dept Internal Med, Taipei, Taiwan

[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Kaohsiung Med Ctr,Div Infect Dis, Tao Yuan, Taiwan

[3] Buddhist Tzu Chi Gen Hosp, Dept Infect Dis, Hualien, Taiwan

[4] Changhua Christian Hosp, Dept Internal Med, Changhua, Taiwan

[5] Chia Yi Christian Hosp, Dept Internal Med, Chiayi, Taiwan

[6] Kaohsiung Med Univ, Chung Ho Mem Hosp, Dept Internal Med, Kaohsiung, Taiwan

[7] Kaohsiung Vet Gen Hosp, Dept Internal Med, Kaohsiung, Taiwan

[8] Tungs Taichung Metro Harbor Hosp, Dept Internal Med, Taichung, Taiwan

[9] Mackay Mem Hosp, Dept Internal Med, Taipei, Taiwan

[10] Pao Chien Hosp, Dept Infect Control, Pingtung, Taiwan

[11] Shin Kong Wu Ho Su Mem Hosp, Dept Internal Med, Taipei, Taiwan

[12] Chang Gung Mem Hosp, Dept Internal Med, Linkou Branch, Tao Yuan, Taiwan

[13] Chi Mei Med Ctr, Dept Internal Med, Tainan, Taiwan

[14] Taipei Med Univ Hosp, Dept Lab Med, Taipei, Taiwan

[15] Taichung Vet Gen Hosp, Dept Internal Med, Taichung, Taiwan

[16] Natl Taiwan Univ Hosp, Dept Internal Med, Yun Lin Branch, Yunlin, Taiwan

[17] Chung Shan Med Univ Hosp, Dept Internal Med, Taichung, Taiwan

[18] Lotung Poh Ai Hosp, Dept Infect Dis, Yilan, Taiwan

[19] Far Eastern Mem Hosp, Dept Internal Med, Taipei, Taiwan

[20] Natl Taiwan Univ, Coll Med, Dept Lab Med, Taipei 10764, Taiwan

[21] Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei 10764, Taiwan

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2008年 / 32卷

关键词：

Tigecycline; Acinetobacter baumannii; Antibacterial drug resistance; Taiwan;

D O I：

10.1016/S0924-8579(08)70026-8

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We performed susceptibility testing using the microdilution method to determine the in-vitro activity of tigecycline against 393 Acinetobacter baumannii clinical isolates collected in 2006 from 19 hospitals in Taiwan. Significant proportions of the isolates were resistant to imipenem (44%), ciprofloxacin (75%), amikacin (69%), sulbactam (34%) and all four antibiotics (22%), and susceptibility to tigecycline among these different resistant phenotypes of A. baumannii varied from 71% to 82%. The minimum inhibitory concentration ( MIC) of tigecycline ranged from 0.6 to 16 mu g/mL (MIC50 2 mu g/mL; MIC90 4 mu g/mL). The cumulative curve of tigecycline MICs showed that when the MIC cut-offs were set at 2 mu g/mL and 4 mu g/mL, 80.9% and 93.1% of the isolates were susceptible, respectively. As tigecycline will be used in the future for infections caused by multidrug-resistant A. baumannii because of limited antibiotic choice, and as resistance to tigecycline in A. baumannii isolates may develop following antibiotic exposure, continuous monitoring of the susceptibility of A. baumannii isolates to tigecycline is warranted. (C) 2008 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：S188 / S191

页数：4

共 31 条

[1] Guidelines for the management, of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia [J].

不详 .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (04) :388-416

[2] Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecycline [J].

Anthony, Kara B. ;

Fishman, Neil O. ;

Linkin, Darren R. ;

Gasink, Leanne B. ;

Edelstein, Paul H. ;

Lautenbach, Ebbing .

CLINICAL INFECTIOUS DISEASES, 2008, 46 (04) :567-570

[3] Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA [J].

Bauer, G ;

Berens, C ;

Projan, SJ ;

Hillen, W .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 (04) :592-599

[4] Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance [J].

Chopra, I ;

Roberts, M .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2001, 65 (02) :232-+

[5]

*CLIN LAB STAND I, 2006, M100S16 CLIN LAB S S

[6] Tigecycline use in critically ill older patients:: Case reports and critical analysis [J].

Curcio, Daniel ;

Fernandez, Francisco ;

Duret, Fernando .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2007, 55 (02) :312-313

[7] Baseline in vitro activity of tigecycline among key bacterial pathogens exhibiting multidrug resistance [J].

Draghi, Deborah C. ;

Tench, Stacy ;

Dowzicky, Michael J. ;

Sahm, Daniel F. .

CHEMOTHERAPY, 2008, 54 (02) :91-100

[8] The changing global epidemiology of Acinetobacter baumannii infections:: a development with major public health implications [J].

Falagas, M. E. ;

Karveli, E. A. .

CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 (02) :117-119

[9] Attributable mortality of Acinetobacter baumannii:: no longer a controversial issue [J].

Falagas, Matthew E. ;

Rafailidis, Petros I. .

CRITICAL CARE, 2007, 11 (03)

[10]

Falagas ME, 2006, CRIT CARE, V10, DOI [10.1186/cc4910, 10.1186/cc4869]

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