COVID-19 Vaccines: Adenoviral Vectors

被引：53

作者：

Jacob-Dolan, Catherine ^{[1
,2
,3
]}

Barouch, Dan H. ^{[1
,2
,3
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2022年 / 73卷

关键词：

PREEXISTING IMMUNITY; SARS-COV-2; INFECTION; SPIKE; MEMORY; CDNA;

D O I：

10.1146/annurev-med-012621-102252

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the unprecedented pace of development of multiple vaccines. This review evaluates how adenovirus (Ad) vector platforms have been leveraged in response to this pandemic. Ad vectors have been used in the past for vaccines against other viruses, most notably HIV and Ebola, but they never have been produced, distributed, or administered to humans at such a large scale. Several different serotypes of Ads encoding SARS-CoV-2 Spike have been tested and found to be efficacious against COVID-19. As vaccine rollouts continue and the number of people receiving these vaccines increases, we will continue to learn about this vaccine platform for COVID-19 prevention and control.

引用

页码：41 / 54

页数：14

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