Molecular mechanisms of lncRNAs in regulating cancer cell radiosensitivity

被引：39
作者：
Zhu, Jiamin [1 ,2 ]
Chen, Shusen [2 ]
Yang, Baixia [2 ]
Mao, Weidong [1 ]
Yang, Xi [3 ]
Cai, Jing [2 ]
机构：
[1] Southeast Univ, Coll Med, Affiliated Jiangyin Hosp, Dept Oncol, 163 Shoushan Rd, Jiangyin 214400, Peoples R China
[2] Nantong Univ, Affiliated Tumor Hosp, Nantong Tumor Hosp, Dept Radiat Oncol, Nantong 226321, Peoples R China
[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, Dept Radiat Oncol,Shanghai Canc Ctr, Shanghai 200032, Peoples R China
来源：
BIOSCIENCE REPORTS | 2019年 / 39卷
基金：
中国国家自然科学基金;
关键词：
LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN COLORECTAL-CANCER; ENHANCES RADIOSENSITIVITY; DOWN-REGULATION; LUNG-CANCER; NASOPHARYNGEAL CARCINOMA; RADIATION-RESISTANCE; TUMOR-CELLS; STEM-CELLS;
D O I：
10.1042/BSR20190590
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Radiotherapy is one of the main modalities of cancer treatment. However, tumor recurrence following radiotherapy occurs in many cancer patients. A key to solving this problem is the optimization of radiosensitivity. In recent years, long non-coding RNAs (lncRNAs), which affect the occurrence and development of tumors through a variety of mechanisms, have become a popular research topic. LncRNAs have been found to influence radiosensitivity by regulating various mechanisms, including DNA damage repair, cell cycle arrest, apoptosis, cancer stem cells regulation, epithelial-mesenchymal transition, and autophagy. LncRNAs are expected to become a potential therapeutic target for radiotherapy in the future. This article reviews recent advances in the role and mechanism of lncRNAs in tumor radiosensitivity.
引用
收藏
页数：9
相关论文
共 79 条
[1]   Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].
Bao, Shideng ;
Wu, Qiulian ;
McLendon, Roger E. ;
Hao, Yueling ;
Shi, Qing ;
Hjelmeland, Anita B. ;
Dewhirst, Mark W. ;
Bigner, Darell D. ;
Rich, Jeremy N. .
NATURE, 2006, 444 (7120) :756-760
[2]   The novel long non-coding RNA TALNEC2, regulates tumor cell growth and the stemness and radiation response of glioma stem cells [J].
Brodie, Shlomit ;
Lee, Hae Kyung ;
Jiang, Wei ;
Cazacu, Simona ;
Xiang, Cunli ;
Poisson, Laila M. ;
Datta, Indrani ;
Kalkanis, Steve ;
Ginsberg, Doron ;
Brodie, Chaya .
ONCOTARGET, 2017, 8 (19) :31798-31814
[3]   Clinical perspectives of cancer stem cell research in radiation oncology [J].
Buetof, Rebecca ;
Dubrovska, Anna ;
Baumann, Michael .
RADIOTHERAPY AND ONCOLOGY, 2013, 108 (03) :388-396
[4]   Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer [J].
Bussink, Johan ;
van der Kogel, Albert J. ;
Kaanders, Johannes H. A. M. .
LANCET ONCOLOGY, 2008, 9 (03) :288-296
[5]   Cancer stem cells and signaling pathways in radioresistance [J].
Chang, Lei ;
Graham, Peter ;
Hao, Jingli ;
Ni, Jie ;
Deng, Junli ;
Bucci, Joseph ;
Malouf, David ;
Gillatt, David ;
Li, Yong .
ONCOTARGET, 2016, 7 (10) :11002-11017
[6]  
Chen CX, 2018, BRAZ J MED BIOL RES, V51, DOI [10.1590/1414-431X20187080, 10.1590/1414-431x20187080]
[7]  
Chen JX, 2015, INT J CLIN EXP PATHO, V8, P7878
[8]   LincRNA-p21 enhances the sensitivity of radiotherapy for gastric cancer by targeting the β-catenin signaling pathway [J].
Chen, Lijun ;
Yuan, Dongfang ;
Yang, Yichen ;
Ren, Minzhu .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (04) :6178-6187
[9]   Long Noncoding RNA FAM201A Mediates the Radiosensitivity of Esophageal Squamous Cell Cancer by Regulating ATM and mTOR Expression via miR-101 [J].
Chen, Mingqiu ;
Liu, Pingping ;
Chen, Yuangui ;
Chen, Zhiwei ;
Shen, Minmin ;
Liu, Xiaohong ;
Li, Xiqing ;
Li, Anchuan ;
Lin, Yu ;
Yang, Rongqiang ;
Ni, Wei ;
Zhou, Xin ;
Zhang, Lurong ;
Tian, Ye ;
Li, Jiancheng ;
Chen, Junqiang .
FRONTIERS IN GENETICS, 2018, 9
[10]   Long non-coding RNAs in anti-cancer drug resistance [J].
Chen, Qin-nan ;
Wei, Chen-chen ;
Wang, Zhao-xia ;
Sun, Ming .
ONCOTARGET, 2017, 8 (01) :1925-1936
12345678