Autophagy and Rheumatoid Arthritis: Current Knowledges and Future Perspectives

被引：83

作者：

Vomero, Marta ^{[1
]}

Barbati, Cristiana ^{[1
]}

Colasanti, Tania ^{[1
]}

Perricone, Carlo ^{[1
]}

Novelli, Lucia ^{[1
]}

Ceccarelli, Fulvia ^{[1
]}

Spinelli, Francesca Romana ^{[1
]}

Di Franco, Manuela ^{[1
]}

Conti, Fabrizio ^{[1
]}

Valesini, Guido ^{[1
]}

Alessandri, Cristiano ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Internal Med & Med Specialties, Rome, Italy

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

关键词：

autophagy; rheumatoid arthritis; autoimmunity; apoptosis; citrullination; MHC CLASS-II; GLUCOCORTICOIDS-INDUCED APOPTOSIS; GENERATES CITRULLINATED PEPTIDES; SYSTEMIC-LUPUS-ERYTHEMATOSUS; T-CELLS; SYNOVIAL FIBROBLASTS; AUTOIMMUNE-DISEASES; THYMIC EPITHELIUM; JOINT DESTRUCTION; INDUCE AUTOPHAGY;

D O I：

10.3389/fimmu.2018.01577

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens. Deregulation of autophagic pathway has recently been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis (RA). Indeed, autophagy seems to be involved in the generation of citrullinated peptides, and also in apoptosis resistance in RA. In this review, we summarize the current knowledge on the role of autophagy in RA and discuss the possibility of a clinical application of autophagy modulation in this disease.

引用

页数：10

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