Glutathione S-transferase, polymorphism in Parkinson's disease

被引：20
作者：
Rahbar, A
Kempkes, M
Müller, T
Reich, S
Welter, FL
Meves, S
Przuntek, H
Bolt, HM
Kuhn, W
机构：
[1] Ruhr Univ Bochum, Dept Neurol, St Josef Hosp, D-44791 Bochum, Germany
[2] Univ Dortmund, Dept Occupat Physiol, Dortmund, Germany
来源：
JOURNAL OF NEURAL TRANSMISSION | 2000年 / 107卷 / 03期
关键词：
Parkinsons disease; glutathione S-transferase; GSTM1; GSTT1;
D O I：
10.1007/s007020050027
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Glutathione S-transferases (GSTs) are involved in the detoxification of endogenous or exogenous toxins, which may play a role in the pathogenesis of Parkinson's disease. We genotyped the Glutathione-S-Transferase isoenzymes GSTM1 and GSTT1 by polymerase chain reaction in order to evaluate different gene polymorphisms of these isoenzymes in 149 parkinsonian and 99 control subjects. No differences appeared between both groups regarding the frequencies of the homozygous deletion of GSTM1 (odds ratio 1.021; 95% CI [0.613; 1.699], p < 0.521 Fisher's exact test) and GSTT1 (odds ratio 1.514; 95% Cl [0.811; 2.824], p < 0.127). Age of onset of PD did not correlate to GSTM1 and GSTT1 polymorphisms. These results do not support the hypothesis of a possible impact of GSTM1 and GSTT1 detoxification activities in the pathogenesis of Parkinson's disease.
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页码：331 / 334
页数：4
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