A large-scale retrospective study of closing-in behavior in Alzheimer's disease

被引:20
|
作者
Ambron, Elisabetta [2 ]
McIntosh, Robert D. [1 ]
Allaria, Francesca [3 ]
Della Sala, Sergio [1 ]
机构
[1] Univ Edinburgh, Dept Psychol, Ctr Cognit Aging & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland
[2] Suor Orsola Benincasa Univ, Expt Psychol Lab, Naples, Italy
[3] Univ Milan, St Paolo Hosp, Neurol Dept 3, Milan, Italy
关键词
Constructional apraxia; Dementia; Attention; Executive functions; Visuospatial abilities; Drawing; ATTRACTION ACCOUNT; DIAGNOSIS; DEMENTIA; CHILDREN; TASK;
D O I
10.1017/S1355617709990245
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The frequency and characteristics of closing-in behavior (CIB) were examined in 797 patients with Alzheimer's disease (AD), 132 of whom were followed up longitudinally. The frequency of CIB increased with the complexity of the graphic copying task and with the severity of Alzheimer's disease. Regression analyses suggested that attentional deficits are critical factors for the appearance of CIB, but that visuospatial impairments also play an important role in the emergence of severe forms of CIB. (JINS, 2009, 15, 787-792.)
引用
收藏
页码:787 / 792
页数:6
相关论文
共 50 条
  • [1] The closing-in phenomenon in the drawing performance of Alzheimer's disease patients: A compensation account
    Serra, Laura
    Fadda, Lucia
    Perri, Roberta
    Caltagirone, Carlo
    Carlesimo, Giovanni A.
    CORTEX, 2010, 46 (08) : 1031 - 1036
  • [2] Closing-in is related to Apathy in Alzheimer's Disease Patients
    Grossi, Dario
    de Lucia, Natascia
    Trojano, Luigi
    JOURNAL OF ALZHEIMERS DISEASE, 2015, 43 (03) : 849 - 855
  • [3] Frontal Defects Contribute to the Genesis of Closing-in in Alzheimer's Disease Patients
    De Lucia, Natascia
    Grossi, Dario
    Fasanaro, Angiola Maria
    Carpi, Sabrina
    Trojano, Luigi
    JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2013, 19 (07) : 802 - 808
  • [4] Closing-in in Parkinson's disease individuals with dementia: An experimental study
    De Lucia, Natascia
    Grossi, Dario
    Mauro, Alfonso
    Trojano, Luigi
    JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 2015, 37 (09) : 946 - 955
  • [5] The Genesis of Closing-In in Alzheimer Disease and Vascular Dementia: A Comparative Clinical and Experimental Study
    De Lucia, Natascia
    Grossi, Dario
    Trojano, Luigi
    NEUROPSYCHOLOGY, 2014, 28 (02) : 312 - 318
  • [6] The closing-in phenomenon in Parkinson's disease
    De Lucia, Natascia
    Trojano, Luigi
    Vitale, Carmine
    Grossi, Dario
    Barone, Paolo
    Santangelo, Gabriella
    PARKINSONISM & RELATED DISORDERS, 2015, 21 (07) : 793 - 796
  • [7] "Closing-in" phenomenon in Alzheimer's disease and subcortical vascular dementia
    Yong Tae Kwak
    BMC Neurology, 4
  • [8] Closing-in Phenomenon in Huntington's Disease: A Neuropsychological Marker of Frontal/Executive Dysfunction
    De Lucia, Natascia
    Peluso, Silvio
    Roca, Alessandro
    Russo, Cinzia Valeria
    Massarelli, Marco
    De Michele, Giovanna
    Di Maio, Luigi
    Salvatore, Elena
    De Michele, Giuseppe
    ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2019, 34 (01) : 24 - 30
  • [9] Long-Term Effects of Galantamine on Cognitive Function in Alzheimer's Disease: A Large-Scale International Retrospective Study
    Kavanagh, Shane
    Van Baelen, Bart
    Schaeuble, Barbara
    JOURNAL OF ALZHEIMERS DISEASE, 2011, 27 (03) : 521 - 530
  • [10] Temporal Irreversibility of Large-Scale Brain Dynamics in Alzheimer's Disease
    Cruzat, Josephine
    Herzog, Ruben
    Prado, Pavel
    Sanz-Perl, Yonatan
    Gonzalez-Gomez, Raul
    Moguilner, Sebastian
    Kringelbach, Morten L.
    Deco, Gustavo
    Tagliazucchi, Enzo
    Ibanez, Agustin
    JOURNAL OF NEUROSCIENCE, 2023, 43 (09): : 1643 - 1656