Challenges for biomarkers in cancer detection

被引：89

作者：

Wagner, PD ^{[1
]}

Verma, M ^{[1
]}

Srivastava, S ^{[1
]}

机构：

[1] NCI, Div Canc Prevent, Canc Biomarkers Res Grp, NIH, Bethesda, MD USA

来源：

CIRCULATING NUCLEIC ACIDS IN PLASMA/SERUM III AND SERUM PROTEOMICS | 2004年 / 1022卷

关键词：

cancer detection; biomarkers;

D O I：

10.1196/annals.1318.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer remains the leading cause of death in the United States. Biomarkers can be used to detect cancer in different stages, initiation, development, and progression. The desirable property and utility of a biomarker lie in its ability to provide an early indication of disease progression. Biomarkers should be easy to detect, measurable across populations, and useful for detection of cancer at an early stage, identification of high-risk individuals, detection of recurrence, or monitoring endpoints in intervention studies. Recent technological advances have helped develop noninvasive, sensitive, and specific biomarkers to detect cancer at early stages of the disease.

引用

页码：9 / 16

页数：8

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