Development of FuGO: An ontology for Functional Genomics Investigations

被引:36
作者
Whetzel, Patricia L. [1 ]
Brinkman, Ryan R.
Causton, Helen C.
Fan, Liju
Field, Dawn
Fostel, Jennifer
Fragoso, Gilberto
Gray, Tanya
Heiskanen, Mervi
Hernandez-Boussard, Tina
Morrison, Norman
Parkinson, Helen
Rocca-Serra, Philippe
Sansone, Susanna-Assunta
Schober, Daniel
Smith, Barry
Stevens, Robert
Stoeckert, Christian J.
Taylor, Chris
White, Joe
Wood, Andrew
机构
[1] Univ Penn, Sch Med, Ctr Bioinformat, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA
[3] British Columbia Canc Res Ctr, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada
[4] Univ London Imperial Coll Sci Technol & Med, Fac Med, MRC, Ctr Clin Sci, London, England
[5] Ontol Workshop LLC, Columbia, MD USA
[6] Oxford Ctr Ecol & Hydrol, Mol Evolut & Bioinformat Sect, Oxford, England
[7] NIEHS, Res Triangle Pk, NC 27709 USA
[8] NCI, Ctr Bioinformat, NCICB, Rockville, MD USA
[9] Stanford Univ, Med Ctr, Dept Genet, Stanford, CA 94305 USA
[10] Univ Manchester, Dept Comp Sci, Manchester, Lancs, England
[11] Oxford Ctr Ecol & Hydrol, NERC, Environm Bioinformat Ctr, Oxford, England
[12] European Bioinformat Inst, Cambridge, England
[13] SUNY Buffalo, Dept Philosophy, Ctr Excellence Bioinformat & Life Sci, Buffalo, NY USA
[14] SUNY Buffalo, Natl Ctr Biomed Oncol, Buffalo, NY USA
[15] Inst Formal Ontol & Med Sci, Saarbrucken, Germany
[16] Dana Farber Canc Inst, Boston, MA 02115 USA
基金
英国自然环境研究理事会;
关键词
D O I
10.1089/omi.2006.10.199
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The development of the Functional Genomics Investigation Ontology (FuGO) is a collaborative, international effort that will provide a resource for annotating functional genomics investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. FuGO will contain both terms that are universal to all functional genomics investigations and those that are domain specific. In this way, the ontology will serve as the "semantic glue" to provide a common understanding of data from across these disparate data sources. In addition, FuGO will reference out to existing mature ontologies to avoid the need to duplicate these resources, and will do so in such a way as to enable their ease of use in annotation. This project is in the early stages of development; the paper will describe efforts to initiate the project, the scope and organization of the project, the work accomplished to date, and the challenges encountered, as well as future plans. This paper is part of the special issue of OMICS on data standards.
引用
收藏
页码:199 / 204
页数:6
相关论文
共 14 条
  • [1] Gene Ontology: tool for the unification of biology
    Ashburner, M
    Ball, CA
    Blake, JA
    Botstein, D
    Butler, H
    Cherry, JM
    Davis, AP
    Dolinski, K
    Dwight, SS
    Eppig, JT
    Harris, MA
    Hill, DP
    Issel-Tarver, L
    Kasarskis, A
    Lewis, S
    Matese, JC
    Richardson, JE
    Ringwald, M
    Rubin, GM
    Sherlock, G
    [J]. NATURE GENETICS, 2000, 25 (01) : 25 - 29
  • [2] BALL CA, 2006, OMICS
  • [3] BRUSKIEWICH R, 2006, OMICS
  • [4] FIEHN O, 2006, OMICS
  • [5] FIELD D, 2006, OMICS
  • [6] KNUBLAUCH H, 2004, INT WORKSH DESCR LOG
  • [7] MORRISON N, 2006, OMICS
  • [8] Noy Natalya F, 2003, AMIA Annu Symp Proc, P953
  • [9] RUBIN DL, 2006, OMICS
  • [10] SANSONE SA, 2006, OMICS