The toxic effect of a mixture of melamine and cyanuric acid on the gastrointestinal tract and liver in mice

被引:15
|
作者
Chang, Lingling [1 ,2 ]
Yue, Zhuo [3 ]
She, Ruiping [1 ]
Sun, Yanyan [1 ]
Zhu, Jinfeng [1 ]
机构
[1] China Agr Univ, Coll Vet Med, Minist Agr, Lab Anim Pathol & Publ Hlth,Key Lab Zoonosis, Beijing 100094, Peoples R China
[2] Northwest A&F Univ, Coll Vet Med, Yangling, Shaanxi, Peoples R China
[3] Beijing Tian Tan Biol Prod Co Ltd, Beijing, Peoples R China
关键词
Melamine; Cyanuric acid; Gastrointestinal tract; Liver; Mice; MORPHOLOGY; APOPTOSIS; ENERGY; CATS; DIET;
D O I
10.1016/j.rvsc.2015.08.018
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The aim of this study was to investigate the effects of a mixture of melamine (MA) and cyanuric acid (CA) on the gastrointestinal tract and liver in mice. Kunming mice were given 0, 10, 100, or 200 mg/kg.bw/day MA and CA mixture (MC, each compound) in corn oil by gavage for 7 consecutive days. Autopsy showed severe renal injury in all MC-treated mice and histopathological examination revealed dose-related lesions in the gastrointestinal tract and liver other than the kidneys. Subsequently, Kunming mice were given 0, 0.3, 1.5, or 7.5 mg/kg.bw/day MC (each compound) in corn oil by gavage for 28 consecutive days. The results showed that higher doses of MC caused mortality and alteration on the body weights, relative liver weights, and blood chemistry parameters related to treatment. Histopathologically, the liver revealed scattered hepatic necrosis and apoptosis. Villous height and villus-to-crypt depth ratios were decreased in the duodenum and jejunum, with marked expression of proliferating cell nuclear antigen in the epithelium compared with controls. In conclusion, MC mixture could cause toxic effects in the gastrointestinal tract and liver in mice during acute and sub-acute toxicity study. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:234 / 237
页数:4
相关论文
共 50 条
  • [41] Effect of dihydrotestosterone on gastrointestinal tract of male Alzheimer's disease transgenic mice
    Karri, Sritulasi
    Acosta-Martinez, Veronica
    Coimbatore, Gopalakrishnan
    INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 2010, 48 (05) : 453 - 465
  • [42] Exposing to Cadmium Stress Cause Profound Toxic Effect on Microbiota of the Mice Intestinal Tract
    Liu, Yehao
    Li, Yuhui
    Liu, Kaiyong
    Shen, Jie
    PLOS ONE, 2014, 9 (02):
  • [43] TOXIC EFFECT OF PHOSPHAMIDE WITH ITS SIMULTANEOUS ENTRANCE INTO ORGANISM THROUGH GASTROINTESTINAL-TRACT AND RESPIRATORY ORGANS
    VOITENKO, GA
    LARIONOV, VG
    FARMAKOLOGIYA I TOKSIKOLOGIYA, 1976, 39 (05): : 622 - 625
  • [44] The effect of intraperitoneally administered microcystin-LR on the gastrointestinal tract of Balb/c mice
    Botha, N
    van de Venter, M
    Downing, TG
    Shephard, EG
    Gehringer, MM
    TOXICON, 2004, 43 (03) : 251 - 254
  • [45] Transcriptomics and metabolomics revealed the molecular mechanism of the toxic effect of mancozeb on liver of mice
    Zhang, Yan
    Bao, Jialu
    Gong, Xincheng
    Shi, Wanyu
    Liu, Tao
    Wang, Xiaodan
    ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2022, 243
  • [46] Effect of passage through the gastrointestinal tract of mice on the viability of Myxobolus cerebralis (Myxozoa) spores
    El-Matbouhi, M
    Sobottka, I
    Schumacher, U
    Schottelius, J
    BULLETIN OF THE EUROPEAN ASSOCIATION OF FISH PATHOLOGISTS, 2005, 25 (06): : 276 - 279
  • [47] Effect of fermented rapeseed meal in the mixture for growing pigs on the gastrointestinal tract, antioxidant status, and immune response
    Anna Czech
    Bożena Nowakowicz-Debek
    Marcin Łukaszewicz
    Mariusz Florek
    Mateusz Ossowski
    Łukasz Wlazło
    Scientific Reports, 12
  • [48] Effect of fermented rapeseed meal in the mixture for growing pigs on the gastrointestinal tract, antioxidant status, and immune response
    Czech, Anna
    Nowakowicz-Debek, Bozena
    Lukaszewicz, Marcin
    Florek, Mariusz
    Ossowski, Mateusz
    Wlazlo, Lukasz
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [49] TOXI 7-Fish: A nonmammalian model for determining a "No Observable Effect Level" (NOEL) for crystal formation in kidneys after exposure to melamine and cyanuric acid
    Reimschuessel, Renate
    Evans, Eric
    Stine, Cynthia B.
    Mayer, Tamara
    Hasbrouck, Nicholas
    Gieseker, Charles
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [50] Ursolic acid improves the bacterial community mapping of the intestinal tract in liver fibrosis mice
    Wan, Sizhe
    Huang, Chenkai
    Wang, Anjiang
    Zhu, Xuan
    PEERJ, 2020, 8