Non-invasive brain stimulation for Parkinson's disease: Clinical evidence, latest concepts and future goals: A systematic review

被引:56
作者
Madrid, Julian [1 ]
Benninger, David H. [1 ]
机构
[1] Ctr Hosp Univ Vaudois CHUV, Dept Clin Neurosci, Serv Neurol, Lausanne, Switzerland
关键词
Parkinson's disease; Non-invasive brain stimulation; rTMS; tDCS; tACS; tRNS; DBS; TRANSCRANIAL MAGNETIC STIMULATION; PRIMARY MOTOR CORTEX; SUBTHALAMIC NUCLEUS STIMULATION; NEUROLOGICAL MANAGEMENT GUIDELINES; ALTERNATING-CURRENT STIMULATION; LEVODOPA-INDUCED DYSKINESIAS; MOVEMENT-RELATED-ACTIVITY; FIELD POTENTIAL ACTIVITY; THETA-BURST STIMULATION; SCIENTIFIC TASK-FORCES;
D O I
10.1016/j.jneumeth.2020.108957
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Parkinson's disease (PD) is becoming a major public-health issue in an aging population. Available approaches to treat advanced PD still have limitations; new therapies are needed. The non-invasive brain stimulation (NIBS) may offer a complementary approach to treat advanced PD by personalized stimulation. Although NIBS is not as effective as the gold-standard levodopa, recent randomized controlled trials show promising outcomes in the treatment of PD symptoms. Nevertheless, only a few NIBS-stimulation paradigms have shown to improve PD's symptoms. Current clinical recommendations based on the level of evidence are reported in Table 1 through Table 3. Furthermore, novel technological advances hold promise and may soon enable the non-invasive stimulation of deeper brain structures for longer periods.
引用
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页数:36
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