Development of Novel Lignin-Based Targeted Polymeric Nanoparticle Platform for Efficient Delivery of Anticancer Drugs

被引：50

作者：

Liu, Kefeng ^{[1
]}

Zheng, Dan ^{[1
]}

Lei, Hantian ^{[1
]}

Liu, Jing ^{[1
]}

Lei, Jiandu ^{[1
]}

Wang, Luying ^{[1
]}

Ma, Xingyuan ^{[2
]}

机构：

[1] Beijing Forestry Univ, Beijing Key Lab Lignocellulos Chem, Beijing 100083, Peoples R China

[2] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

ACS BIOMATERIALS SCIENCE & ENGINEERING | 2018年 / 4卷 / 05期

基金：

中国国家自然科学基金;

关键词：

polymeric nanoparticle; drug delivery; lignin; renewable biopolymer; self-assembly; hydroxyl camptothecin; DOCETAXEL-CARBOXYMETHYLCELLULOSE NANOPARTICLE; CHITOSAN NANOPARTICLES; CANCER; BIODISTRIBUTION; PACLITAXEL; EFFICACY;

D O I：

10.1021/acsbiomaterials.8b00260

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The clinical applications of natural anticancer drugs are being restricted by poor water solubility, fast clearance in the circulation, lack of targeting to tumor cells, and poor tissue penetration. To address these problems, in this study, we developed a novel lignin-based targeted polymeric nanoparticles (NPs) platform, folic acid-polyethylene glycol-alkaline lignin conjugates (FA-PEG-AL), via self-assembly for delivery of anticancer drug (hydroxyl camptothecin, HCPT). These lignin-based nanoparticles had moderate particle size (similar to 150 nm) with a narrow size distribution (PDI < 0.1), exhibited excellent biocompatibility, high drug loading efficiency (similar to 24.2 wt % of HCPT), prolonged blood circulation time (similar to 7-fold of free HCPT), and enhanced cellular uptake (similar to 5-fold of free HCPT). Besides, the drug biodistribution study confirmed preferred accumulation of FA-PEG-AL/HCPT NPs in tumor tissue. Subsequent tumor xenograft test revealed superior tumor suppression efficacy and reduced side effects of FAPEG-AL/HCPT NPs compared with free HCPT. Therefore, the prepared lignin-based FA-PEG-AL/HCPT NPs would be a promising candidate for anticancer drugs delivery.

引用

页码：1730 / 1737

页数：15

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