Euphosantianane E-G: Three New Premyrsinane Type Diterpenoids from Euphorbia sanctae-catharinae with Contribution to Chemotaxonomy

被引：17

作者：

Elshamy, Abdelsamed I. ^{[1
]}

Mohamed, Tarik A. ^{[2
]}

Al-Rowaily, Saud L. ^{[3
]}

Abd-ElGawad, Ahmed M. ^{[3
,4
]}

Dar, Basharat A. ^{[3
]}

Shahat, Abdelaaty A. ^{[2
,5
]}

Hegazy, Mohamed-Elamir F. ^{[2
,6
]}

机构：

[1] Natl Res Ctr, Nat Cpds Chem Dept, 33 El Bohouth St, Giza 12622, Egypt

[2] Natl Res Ctr, Chem Med Plants Dept, 33 El Bohouth St, Giza 12622, Egypt

[3] King Saud Univ, Plant Prod Dept, Coll Food & Agr Sci, POB 2460, Riyadh 11451, Saudi Arabia

[4] Mansoura Univ, Dept Bot, Fac Sci, Mansoura 35516, Egypt

[5] King Saud Univ, Dept Pharmacognosy, Coll Pharm, POB 2457, Riyadh 11451, Saudi Arabia

[6] Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Pharmaceut Biol, Staudinger Weg 5, D-55128 Mainz, Germany

来源：

MOLECULES | 2019年 / 24卷 / 13期

关键词：

endemic plant; Euphorbia sanctae-catharinae; euphorbiaceae; premyrsinane diterpenoids; euphosantianane E-G; chemotaxonomic significance; JATROPHANE DITERPENES; MULTIDRUG-RESISTANCE; ANTIBACTERIAL ACTIVITY; INHIBITORY-ACTIVITIES; MYRSINOL DITERPENES; MEDICINAL-PLANTS; SINAI PENINSULA; PROLIFERA; ROOTS; TRITERPENES;

D O I：

10.3390/molecules24132412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Euphorbia species were widely used in traditional medicines for the treatment of several diseases. From the aerial parts of Egyptian endemic plant, Euphorbia sanctae-catharinae, three new premyrsinane diterpenoids, namely, euphosantianane E-G (1-3), alongside four known triterpenes, 9,19-cyclolanostane-3 beta,24S-diol (4), 25-methoxycycloartane-3 beta,24S-diol (5), 25-methylenecycloartan-3 beta,24R-diol (6), and 25-methylenecycloartan-3 beta,24S-diol (7), were isolated and identified. The chemical structures were proven depending upon spectroscopic analysis, including FTIR, HRFABMS, and 1D/2D-NMR. The chemotaxonomic significance of the isolated compounds, especially diterpenes from E. sanctae-catharinae compared to those documented from different Euphorbia species was also studied via agglomerative hierarchical clustering (AHC). The Egyptian endemic Euphorbia sanctae-catharina was grouped with E. bupleuroides, E. fidjiana, E. fischeriana, E. pithyusa subsp. cupanii, E. prolifera, and E. seguieriana, where myrsinol diterpenoids were the characteristic compounds.

引用

页数：13

共 1 条

[1] Euphosantianane A-D: Antiproliferative Premyrsinane Diterpenoids from the Endemic Egyptian Plant Euphorbia Sanctae-Catharinae
Hegazy, Mohamed-Elamir F.
Hamed, Ahmed R.
Ibrahim, Mahmoud A. A.
Talat, Zienab
Reda, Eman H.
Abdel-Azim, Nahla S.
Hammouda, Faiza M.
Nakamura, Seikou
Matsuda, Hisashi
Haggag, Eman G.
Pare, Paul W.
Efferth, Thomas
MOLECULES, 2018, 23 (09):

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