Exploring the Association between Severe Respiratory Syncytial Virus Infection and Asthma A Registry-based Twin Study

被引：138

作者：

Thomsen, Simon Francis ^{[1
]}

van der Sluis, Sophie ^{[2
]}

Stensballe, Lone G. ^{[3
]}

Posthuma, Danielle ^{[2
]}

Skytthe, Axel ^{[4
]}

Kyvik, Kirsten O. ^{[4
,5
]}

Duffy, David L. ^{[7
]}

Backer, Vibeke ^{[1
]}

Bisgaard, Hans ^{[6
]}

机构：

[1] Bispebjerg Hosp, Dept Resp Med, DK-2400 Copenhagen NV, Denmark

[2] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

[3] Statens Serum Inst, Danish Epidemiol Sci Ctr, DK-2300 Copenhagen, Denmark

[4] Univ So Denmark, Danish Twin Registry, Odense, Denmark

[5] Univ So Denmark, Inst Reg Hlth Res Serv, Odense, Denmark

[6] Univ Copenhagen Hosp, Danish Pediat Asthma Ctr, Gentofte, Denmark

[7] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2009年 / 179卷 / 12期

基金：

英国医学研究理事会;

关键词：

RSV infection; asthma; twin study; genetic; direction of causation; SUSCEPTIBILITY; BRONCHIOLITIS; WHEEZE;

D O I：

10.1164/rccm.200809-1471OC

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Rationale: Severe respiratory syncytial virus (RSV) infection is associated with asthma but the nature of this association is imperfectly understood. Objectives: To examine the nature of the association between severe RSV infection and asthma in a population-based sample of twins. Methods: Data on hospitalization due to RSV infection was gathered for all twins born in Denmark between 1994 and 2000 (8,280 pairs) and linked to information on asthma obtained from hospital discharge registries and parent-completed questionnaires. Genetic variance components models and direction of causation models were fitted to the observed data. Measurements and Main Results: RSV hospitalization and asthma were positively associated (r = 0.43), and genetic determinants for the two disorders overlapped completely. Modeling the direction of causation between RSV hospitalization and asthma showed that a model in which asthma "causes" RSV hospitalization fitted the data significantly better (P = 0.39 for deterioration in model fit) than a model in which RSV hospitalization "causes" asthma (P < 0.001 for deterioration in model fit), even when sex, birth weight, and maternal smoking during pregnancy were accounted for. Conclusions: RSV infection that is severe enough to warrant hospitalization does not cause asthma but is an indicator of the genetic predisposition to asthma.

引用

页码：1091 / 1097

页数：7

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