TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?

被引：138
作者：
Winter, E [1 ]
Ponting, CR [1 ]
机构：
[1] Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 08期
关键词：
D O I：
10.1016/S0968-0004(02)02154-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.
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收藏
页码：381 / 383
页数：3
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