Systematic study of the reactivity of (E)-4,4,4-trifluorobut-2-en-1-yl 4-methylbenzenesulfonate towards different classes of nucleophiles

被引：5

作者：

Forcellini, Elsa ^{[1
]}

Hemelaere, Remy ^{[1
]}

Desroches, Justine ^{[1
]}

Paquin, Jean-Francois ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, PROTEO, CCVC, Quebec City, PQ G1V 0A6, Canada

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2015年 / 180卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Trifluoromethyl group; Allylic tosylate; Substitution reaction; Nucleophile; Allylic substitution; TRIFLUOROMETHYL GROUP; LIQUID-CRYSTALS; CHAIN;

D O I：

10.1016/j.jfluchem.2015.10.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A systematic study of the reactivity of (E)-4,4,4-trifluorobut-2-en-1-yl 4-methylbenzenesulfonate towards different classes of nucleophiles (alcohols, amines, thiols and malonates) was performed. A single set of reaction conditions (with small variations) allowed the isolation of the substitution product in moderate to good yields for all the nucleophiles tested with the exception of benzyl alcohol and indole. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：216 / 221

页数：6

共 13 条

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