Field accuracy of fourth-generation rapid diagnostic tests for acute HIV-1: a systematic review

被引：27

作者：

Lewis, Joseph M. ^{[1
,2
]}

Macpherson, Peter ^{[2
,3
]}

Adams, Emily R. ^{[4
]}

Ochodo, Eleanor ^{[5
]}

Sands, Anita ^{[6
]}

Taegtmeyer, Miriam ^{[2
]}

机构：

[1] Univ Liverpool, Liverpool Sch Trop Med, Wellcome Trust Trop Ctr, Liverpool L3 5QA, Merseyside, England

[2] Univ Liverpool, Liverpool Sch Trop Med, Dept Clin Sci, Liverpool L3 5QA, Merseyside, England

[3] Univ Liverpool, Dept Publ Hlth & Policy, Liverpool L3 5QA, Merseyside, England

[4] Univ Liverpool, Liverpool Sch Trop Med, Dept Parasitol, Liverpool L3 5QA, Merseyside, England

[5] Univ Stellenbosch, Fac Med & Hlth Sci, Ctr Evidence Based Healthcare, Cape Town, South Africa

[6] WHO, Dept Essential Med & Hlth Prod, CH-1211 Geneva, Switzerland

来源：

AIDS | 2015年 / 29卷 / 18期

基金：

英国惠康基金;

关键词：

acute infection; diagnostic accuracy; HIV; point-of-care testing; rapid diagnostic tests; systematic review; CARE; INFECTION; PERFORMANCE; POINT; EXPERIENCE; ANTIGEN; BLOOD; ASSAY; TOOL;

D O I：

10.1097/QAD.0000000000000855

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Introduction:Fourth-generation HIV-1 rapid diagnostic tests (RDTs) detect HIV-1 p24 antigen to screen for acute HIV-1. However, diagnostic accuracy during clinical use may be suboptimal.Methods:Clinical sensitivity and specificity of fourth-generation RDTs for acute HIV-1 were collated from field evaluation studies in adults identified by a systematic literature search.Results:Four studies with 17381 participants from Australia, Swaziland, the United Kingdom and Malawi were identified. All reported 0% sensitivity of the HIV-1 p24 component for acute HIV-1 diagnosis; 26 acute infections were missed. Specificity ranged from 98.3 to 99.9%.Conclusion:Fourth-generation RDTs are currently unsuitable for the detection of acute HIV-1.

引用

页码：2465 / 2471

页数：7

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