Ageing and adrenal cortical function

被引：11
作者：
Svec, F
机构：
[1] Section of Endocrinology, Louisiana State University, Medical School, New Orleans, LA 70112
来源：
BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM | 1997年 / 11卷 / 02期
关键词：
adrenal gland; cortisol; dehydroepiandrosterone; ageing; dehydroepiandrosterone sulphate;
D O I：
10.1016/S0950-351X(97)80287-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ageing is associated with changes in the secretion of adrenal cortical steroids, In the elderly, cortisol secretion increases after stimulation, while the secretion of dehydroepiandrosterone (DHEA) decreases. Each of these hormones influences the age-related processes of energy metabolism, fat depot distribution, immune function and neurodegeneration. In animals the effects of adrenal steroids are dramatic and easily measured. In humans the effects are more subtle. This review summarizes these actions and emphasizes the differences of dosages used in various experimental designs. It is concluded that adrenal hormones may play a significant role in human ageing, but research is hindered because the molecular pathways of DHEA action are not known.
引用
收藏
页码：271 / 287
页数：17
相关论文
共 89 条
[1]   NEUROSTEROIDS - BIOSYNTHESIS, METABOLISM AND FUNCTION OF PREGNENOLONE AND DEHYDROEPIANDROSTERONE IN THE BRAIN [J].
AKWA, Y ;
YOUNG, J ;
KABBADJ, K ;
SANCHO, MJ ;
ZUCMAN, D ;
VOURCH, C ;
JUNGTESTAS, I ;
HU, ZY ;
LEGOASCOGNE, C ;
JO, DH ;
CORPECHO, C ;
SIMON, P ;
BAULIEU, EE ;
ROBEL, P .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1991, 40 (1-3) :71-81
[2]   DEHYDROEPIANDROSTERONE-SULFATE DOES NOT PREDICT CARDIOVASCULAR DEATH IN POSTMENOPAUSAL WOMEN - THE RANCHO-BERNARDO STUDY [J].
BARRETTCONNOR, E ;
GOODMANGRUEN, D .
CIRCULATION, 1995, 91 (06) :1757-1760
[3]   The epidemiology of DHEAS and cardiovascular disease [J].
BarrettConnor, E ;
GoodmanGruen, D .
DEHYDROEPIANDROSTERONE (DHEA) AND AGING, 1995, 774 :259-270
[4]   A PROSPECTIVE-STUDY OF DEHYDROEPIANDROSTERONE SULFATE, MORTALITY, AND CARDIOVASCULAR-DISEASE [J].
BARRETTCONNOR, E ;
KHAW, KT ;
YEN, SSC .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (24) :1519-1524
[5]   NEUROSTEROIDS - A NEW FUNCTION IN THE BRAIN [J].
BAULIEU, EE .
BIOLOGY OF THE CELL, 1991, 71 (1-2) :3-10
[6]   Dehydroepiandrosterone reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen in men [J].
Beer, NA ;
Jakubowicz, DJ ;
Matt, DW ;
Beer, RM ;
Nestler, JE .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1996, 311 (05) :205-210
[7]  
BELANGER A, 1994, J CLIN ENDOCR METAB, V79, P1086
[8]  
Bernton E, 1995, ANN NY ACAD SCI, V774, P217
[9]   EFFECTS OF AGE AND GENDER ON PITUITARY-ADRENOCORTICAL RESPONSIVENESS IN HUMANS [J].
BORN, J ;
DITSCHUNEIT, I ;
SCHREIBER, M ;
DODT, C ;
FEHM, HL .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1995, 132 (06) :705-711
[10]   REPLACEMENT OF DEHYDROEPIANDROSTERONE ENHANCES T-LYMPHOCYTE INSULIN BINDING IN POSTMENOPAUSAL WOMEN [J].
CASSON, PR ;
FAQUIN, LC ;
STENTZ, FB ;
STRAUGHN, AB ;
ANDERSEN, RN ;
ABRAHAM, GE ;
BUSTER, JE .
FERTILITY AND STERILITY, 1995, 63 (05) :1027-1031
123456789