Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts

被引：58
作者：
An, Min Ji
Cheon, Jae Hee [1 ]
Kim, Seung Won
Kim, Eun Soo
Kim, Tae Il
Kim, Won Ho
机构：
[1] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea
来源：
CANCER LETTERS | 2009年 / 279卷 / 01期
关键词：
Guggulsterone; Colorectal cancer; Apoptosis; Xenograft; FACTOR-KAPPA-B; PLANT COMMIPHORA-MUKUL; ACTIVATION; KINASE; BCL-2; CLEAVAGE; PATHWAY; CHOLESTEROL; CONSTITUENT; SUPPRESSION;
D O I：
10.1016/j.canlet.2009.01.026
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：93 / 100
页数：8
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