Can 18F-FDG PET improve the evaluation of suspicious breast lesions on MRI?

被引:20
作者
Bitencourt, Almir G. V. [1 ]
Lima, Eduardo N. P. [1 ]
Chojniak, Rubens [1 ]
Marques, Elvira F. [1 ]
Souza, Juliana A. [1 ]
Andrade, Wesley P. [2 ]
Guimaraes, Marcos D. [1 ]
机构
[1] Hosp AC Camargo Fund Antonio Prudente, Fdn Antonio Prudente, Dept Diagnost Imaging, BR-01509010 Sao Paulo, Brazil
[2] Hosp AC Camargo Fund Antonio Prudente, Fdn Antonio Prudente, Dept Mastol, BR-01509010 Sao Paulo, Brazil
关键词
Breast cancer; Magnetic resonance imaging; Positron-emission tomography; Prone position; Fluorodeoxyglucose F18; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET; F-18-FDG PET/CT; CANCER; MAMMOGRAPHY; METAANALYSIS; DIAGNOSIS; ESTROGEN; FUSION;
D O I
10.1016/j.ejrad.2014.05.021
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: To evaluate the impact of adding 18F-fluorine-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in the evaluation of suspicious breast lesions on magnetic resonance imaging (MRI). Methods: Sixty patients with suspicious breast lesions on MRI were selected to perform a PET-CT in prone position, dedicated to the evaluation of the breasts. The areas with increased 18F-FDG concentration relative to normal parenchyma were considered positive on PET-CT. Fusion of PET and MRI images (PET-MRI) was performed on a dedicated workstation to better locate corresponding lesions, and its findings were compared with histological results. Results: 76 lesions were evaluated, including 64 mass lesions (84.2%) and 12 non-mass lesions (15.8%). Lesions mean diameter on MRI was 29.6 +/- 19.2 mm (range 6-94 mm). PET-CT showed increased metabolically activity on 57 lesions (75.0%), with mean maximum SUV of 5.7 +/- 5.0 (range 0.8-23.1). On histopathology, there were 17 (22.4%) benign and 59 (79.7%) malignant lesions. Considering all lesions, PET-MRI fusion provided 89.8% sensitivity, 76.5% specificity and 86.8% accuracy. Considering only mass lesions higher than 10 mm, PET-MRI fusion provided 95.8% sensitivity, 83.3% specificity and 93.3% accuracy. Conclusion: The inclusion of 18F-FDG PET on the evaluation of suspicious breast lesions on MRI helped to differentiate benign from malignant breast lesions, especially for mass lesions with a diameter higher than 10 mm. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1381 / 1386
页数:6
相关论文
共 25 条
[1]   False-Positive Lesions Mimicking Breast Cancer on FDG PET and PET/CT [J].
Adejolu, Margaret ;
Huo, Lei ;
Rohren, Eric ;
Santiago, Lumarie ;
Yang, Wei T. .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2012, 198 (03) :W304-W314
[2]   Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters [J].
Basu, Sandip ;
Chen, Wengen ;
Tchou, Julia ;
Mavi, Ayse ;
Cermik, Tevfik ;
Czerniecki, Brian ;
Schnall, Mitchell ;
Alavi, Abass .
CANCER, 2008, 112 (05) :995-1000
[3]   High-resolution fluorodeoxyglucose positron emission tomography with compression ("positron emission mammography") is highly accurate in depicting primary breast cancer [J].
Berg, Wendie A. ;
Weinberg, Irving N. ;
Narayanan, Deepa ;
Lobrano, Mary E. ;
Ross, Eric ;
Amodei, Laura ;
Tafra, Lorraine ;
Adler, Lee P. ;
Uddo, Joseph ;
Stein, William, III ;
Levine, Edward A. .
BREAST JOURNAL, 2006, 12 (04) :309-323
[4]   Follow-up of women with breast cancer: comparison between MRI and FDG PET [J].
Goerres, GW ;
Michel, SCA ;
Fehr, MK ;
Kaim, AH ;
Steinert, HC ;
Seifert, B ;
von Schulthess, GK ;
Kubik-Huch, RA .
EUROPEAN RADIOLOGY, 2003, 13 (07) :1635-1644
[5]   Diagnostic accuracy of fused positron emission tomography/magnetic resonance mammography: initial results [J].
Heusner, T. A. ;
Hahn, S. ;
Jonkmanns, C. ;
Kuemmel, S. ;
Otterbach, F. ;
Hamami, M. E. ;
Stahl, A. R. ;
Bockisch, A. ;
Forsting, M. ;
Antoch, G. .
BRITISH JOURNAL OF RADIOLOGY, 2011, 84 (998) :126-135
[6]   Breast MRI and 18F FDG PET/CT in the management of breast cancer [J].
Iagaru, Andrei ;
Masamed, Rinat ;
Keesara, Sravanthi ;
Conti, Peter S. .
ANNALS OF NUCLEAR MEDICINE, 2007, 21 (01) :33-38
[7]   Dual-Time-Point 18F-FDG PET/CT Versus Dynamic Breast MRI of Suspicious Breast Lesions [J].
Imbriaco, Massimo ;
Caprio, Maria Grazia ;
Limite, Gennaro ;
Pace, Leonardo ;
De Falco, Teresa ;
Capuano, Ermanno ;
Salvatore, Marco .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2008, 191 (05) :1323-1330
[8]   Improved detection of breast cancer on FDG-PET cancer screening using breast positioning device [J].
Kaida, Hayato ;
Ishibashi, Masatoshi ;
Fujii, Teruhiko ;
Kurata, Seiji ;
Ogo, Etsuyo ;
Tanaka, Maki ;
Hayabuchi, Naofumi .
ANNALS OF NUCLEAR MEDICINE, 2008, 22 (02) :95-101
[9]   Usefulness of 18F-FDG uptake with clinicopathologic and immunohistochemical prognostic factors in breast cancer [J].
Kim, Bom Sahn ;
Sung, Sun Hee .
ANNALS OF NUCLEAR MEDICINE, 2012, 26 (02) :175-183
[10]   Clinicopathologic factors associated with false negative FDG-PET in primary breast cancer [J].
Kumar, Rakesh ;
Chauhan, Anil ;
Zhuang, Hongming ;
Chandra, Prem ;
Schnall, Mitchell ;
Alavi, Abass .
BREAST CANCER RESEARCH AND TREATMENT, 2006, 98 (03) :267-274