Ultrasound-assisted tandem synthesis of tri- and tetra-substituted pyrrole-2-carbonitriles from alkenes, TMSCN and N,N-disubstituted formamides

被引：39

作者：

Gui, Qing-Wen ^{[1
]}

Teng, Fan ^{[1
]}

Ying, Sheng-Neng ^{[1
]}

Liu, Yang ^{[1
]}

Guo, Tao ^{[1
]}

Tang, Jian-Xin ^{[2
]}

Chen, Jin-Yang ^{[3
]}

Cao, Zhong ^{[3
]}

He, Wei-Min ^{[3
]}

机构：

[1] Hunan Agr Univ, Coll Chem & Mat Sci, Changsha 410128, Peoples R China

[2] Hunan Univ Technol, Sch Life Sci & Chem, Zhuzhou 412007, Peoples R China

[3] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2020年 / 31卷 / 12期

关键词：

Green chemistry; Solvent-free; Tandem reaction; Dual role; Ultrasound; POLYSUBSTITUTED PYRROLES; RADICAL CYCLIZATION; MULTISUBSTITUTED PYRROLES; EFFICIENT SYNTHESIS; ANNULATION; OXIDATION; CF3SO2NA; CATALYST; STYRENES; SOLVENT;

D O I：

10.1016/j.cclet.2020.07.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An energy-saving and eco-friendly method for the efficient construction of various tri- and tetra-substituted pyrrolecarbonitriles through ultrasound-assisted multicomponent tandem reaction of readily available alkenes, TMSCN and N,N-disubstituted formamides within 40 min under metal-, solvent-free and mild conditions was developed. The dual role of iodine (catalyst and oxidant) notably simplified the reaction conditions and reduced the chemical waste generated (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：3241 / 3244

页数：4

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