New perspectives: systems medicine in cardiovascular disease

被引：14

作者：

Kramer, Frank ^{[1
]}

Just, Steffen ^{[2
]}

Zeller, Tanja ^{[3
,4
]}

机构：

[1] Univ Med Ctr Gottingen, Dept Med Stat, Humboldtallee 32, Gottingen, Germany

[2] Univ Ulm, Dept Med 2, Mol Cardiol, Ulm, Germany

[3] Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Martinistr 52, D-20246 Hamburg, Germany

[4] German Ctr Cardiovasc Res DZHK eV, Partner Site Hamburg, Hamburg, Germany

来源：

BMC SYSTEMS BIOLOGY | 2018年 / 12卷

关键词：

ONLINE MENDELIAN INHERITANCE; CORONARY-ARTERY-DISEASE; INTEGRIN-LINKED KINASE; LARGE ANIMAL-MODELS; GENE-EXPRESSION; COMMUNITY STANDARD; CARDIAC MYOCYTE; MAN OMIM; BIG DATA; BIOLOGY;

D O I：

10.1186/s12918-018-0579-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Cardiovascular diseases (CVD) represent one of the most important causes of morbidity and mortality worldwide. Innovative approaches to increase the understanding of the underpinnings of CVD promise to enhance CVD risk assessment and might pave the way to tailored therapies. Within the last years, systems medicine has emerged as a novel tool to study the genetic, molecular and physiological interactions. Conclusion: In this review, we provide an overview of the current molecular-experimental, epidemiological and bioinformatical tools applied in systems medicine in the cardiovascular field. We will discuss the status and challenges in implementing interdisciplinary systems medicine approaches in CVD.

引用

页数：13

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