Fibrostenotic strictures in Crohn's disease

被引：26
作者：
Yoo, Jun Hwan [1 ]
Holubar, Stefan [2 ]
Rieder, Florian [3 ]
机构：
[1] CHA Univ, Sch Med, CHA Bundang Med Ctr, Digest Dis Ctr, 59 Yatap Ro, Seongnam 13496, South Korea
[2] Cleveland Clin Fdn, Digest Dis & Surg Inst, Dept Colorectal Surg, 9500 Euclid Ave, Cleveland, OH 44195 USA
[3] Cleveland Clin Fdn, Digest Dis & Surg Inst, Dept Gastroenterol Hepatol & Nutr, 9500 Euclid Ave, Cleveland, OH 44195 USA
来源：
INTESTINAL RESEARCH | 2020年 / 18卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
Crohn disease; Stricture; Fibrostenosis; Intestinal fibrosis; Endoscopic balloon dilatation; INFLAMMATORY-BOWEL-DISEASE; INHIBITING FIBROBLAST PROLIFERATION; MAGNETIC-RESONANCE ENTEROGRAPHY; INTESTINAL FIBROSIS; LONG-TERM; MATRIX-STIFFNESS; POSTOPERATIVE RECURRENCE; CONTRAST ULTRASONOGRAPHY; ANASTOMOTIC STRICTURES; CONSERVATIVE SURGERY;
D O I：
10.5217/ir.2019.09148
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The use of biologic agents including anti-tumor necrosis factor monoclonal antibodies followed by anti-integrins and anti-interleukins has drastically changed the treatment paradigm of Crohn's disease (CD) by improving clinical symptoms and mucosal healing. However, up to 70% of CD patients still eventually undergo surgery mainly due to fibrostenotic strictures. There are no specific anti-fibrotic drugs yet. This review comprehensively addresses the mechanism, prediction, diagnosis and treatment of the fibrostenotic strictures in CD. We also introduce promising anti-fibrotic agents which may be available in the near future and summarize challenges in developing novel therapies to treat fibrostenotic strictures in CD.
引用
收藏
页码：379 / 401
页数：23
相关论文
共 184 条
[1]   Computed tomography enterography findings correlate with tissue inflammation, not fibrosis in resected small bowel Crohn's disease [J].
Adler, Jeremy ;
Punglia, Darashana R. ;
Dillman, Jonathan R. ;
Polydorides, Alexandros D. ;
Dave, Maneesh ;
Al-Hawary, Mahmoud M. ;
Platt, Joel F. ;
McKenna, Barbara J. ;
Zimmermann, Ellen M. .
INFLAMMATORY BOWEL DISEASES, 2012, 18 (05) :849-856
[2]   The Prognostic Power of the NOD2 Genotype for Complicated Crohn's Disease: A Meta-Analysis [J].
Adler, Jeremy ;
Rangwalla, Sujal C. ;
Dwamena, Ben A. ;
Higgins, Peter D. R. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2011, 106 (04) :699-712
[3]   Magnetization Transfer Helps Detect Intestinal Fibrosis in an Animal Model of Crohn Disease [J].
Adler, Jeremy ;
Swanson, Scott D. ;
Schmiedlin-Ren, Phyllissa ;
Higgins, Peter D. R. ;
Golembeski, Christopher P. ;
Polydorides, Alexandros D. ;
McKenna, Barbara J. ;
Hussain, Hero K. ;
Verrot, Trevor M. ;
Zimmermann, Ellen M. .
RADIOLOGY, 2011, 259 (01) :127-135
[4]  
Allez M, 2002, AM J GASTROENTEROL, V97, P947
[5]   Noninvasive Multimodal Methods to Differentiate Inflamed vs Fibrotic Strictures in Patients With Crohn's Disease [J].
Allocca, Mariangela ;
Fiorino, Gionata ;
Bonifacio, Cristiana ;
Peyrin-Biroulet, Laurent ;
Danese, Silvio .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2019, 17 (12) :2397-2415
[6]   Crohn's disease patients carrying Nod2/CARD15 gene variants have an increased and early need for first surgery due to stricturing disease and higher rate of surgical recurrence [J].
Alvarez-Lobos, M ;
Arostegui, JI ;
Sans, M ;
Tassies, D ;
Plaza, S ;
Delgado, S ;
Lacy, AM ;
Pique, JM ;
Yagüe, J ;
Panés, J .
ANNALS OF SURGERY, 2005, 242 (05) :693-700
[7]   A Comprehensive Review of Strictureplasty Techniques in Crohn's Disease: Types, Indications, Comparisons, and Safety [J].
Ambe, Ronald ;
Campbell, Lorna ;
Cagir, Burt .
JOURNAL OF GASTROINTESTINAL SURGERY, 2012, 16 (01) :209-217
[8]  
[Anonymous], 2003, GUT
[9]   Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn's disease [J].
Ardizzone, S ;
Maconi, G ;
Sampietro, GM ;
Russo, A ;
Radice, E ;
Colombo, E ;
Imbesi, V ;
Molteni, M ;
Danelli, PG ;
Taschieri, AM ;
Porro, GB .
GASTROENTEROLOGY, 2004, 127 (03) :730-740
[10]   Constitutive TL1A Expression under Colitogenic Conditions Modulates the Severity and Location of Gut Mucosal Inflammation and Induces Fibrostenosis [J].
Barrett, Robert ;
Zhang, Xiaolan ;
Koon, Hon Wai ;
Vu, Michelle ;
Chang, Jyh-Yau ;
Yeager, Nicole ;
Nguyen, Mary Ann ;
Michelsen, Kathrin S. ;
Berel, Dror ;
Pothoulakis, Charalabos ;
Targan, Stephan R. ;
Shih, David Q. .
AMERICAN JOURNAL OF PATHOLOGY, 2012, 180 (02) :636-649
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