Fibrostenotic strictures in Crohn's disease

被引：50
作者：
Yoo, Jun Hwan [1 ]
Holubar, Stefan [2 ]
Rieder, Florian [3 ]
机构：
[1] CHA Univ, Sch Med, CHA Bundang Med Ctr, Digest Dis Ctr, 59 Yatap Ro, Seongnam 13496, South Korea
[2] Cleveland Clin Fdn, Digest Dis & Surg Inst, Dept Colorectal Surg, 9500 Euclid Ave, Cleveland, OH 44195 USA
[3] Cleveland Clin Fdn, Digest Dis & Surg Inst, Dept Gastroenterol Hepatol & Nutr, 9500 Euclid Ave, Cleveland, OH 44195 USA
来源：
INTESTINAL RESEARCH | 2020年 / 18卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
Crohn disease; Stricture; Fibrostenosis; Intestinal fibrosis; Endoscopic balloon dilatation; INFLAMMATORY-BOWEL-DISEASE; INHIBITING FIBROBLAST PROLIFERATION; MAGNETIC-RESONANCE ENTEROGRAPHY; INTESTINAL FIBROSIS; LONG-TERM; MATRIX-STIFFNESS; POSTOPERATIVE RECURRENCE; CONTRAST ULTRASONOGRAPHY; ANASTOMOTIC STRICTURES; CONSERVATIVE SURGERY;
D O I：
10.5217/ir.2019.09148
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The use of biologic agents including anti-tumor necrosis factor monoclonal antibodies followed by anti-integrins and anti-interleukins has drastically changed the treatment paradigm of Crohn's disease (CD) by improving clinical symptoms and mucosal healing. However, up to 70% of CD patients still eventually undergo surgery mainly due to fibrostenotic strictures. There are no specific anti-fibrotic drugs yet. This review comprehensively addresses the mechanism, prediction, diagnosis and treatment of the fibrostenotic strictures in CD. We also introduce promising anti-fibrotic agents which may be available in the near future and summarize challenges in developing novel therapies to treat fibrostenotic strictures in CD.
引用
收藏
页码：379 / 401
页数：23
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