Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology

被引:174
作者
Fukuto, Jon M. [1 ]
Ignarro, Louis J. [2 ]
Nagy, Peter [3 ]
Wink, David A. [4 ]
Kevil, Christopher G. [5 ]
Feelisch, Martin [6 ]
Cortese-Krott, Miriam M. [7 ]
Bianco, Christopher L. [7 ]
Kumagai, Yoshito [8 ]
Hobbs, Adrian J. [9 ]
Lin, Joseph [10 ]
Ida, Tomoaki [11 ]
Akaike, Takaaki [11 ]
机构
[1] Sonoma State Univ, Dept Chem, Rohnert Pk, CA 94928 USA
[2] Univ Calif Los Angeles, Ctr Hlth Sci, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90024 USA
[3] Natl Inst Oncol, Dept Mol Immunol & Toxicol, Budapest, Hungary
[4] NCI, Tumor Biol Sect, Radiat Biol Branch, Bethesda, MD 20892 USA
[5] Louisiana Statue Univ, Hlth Sci Ctr, Dept Pathol, Shreveport, LA USA
[6] Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England
[7] Heinrich Heine Univ, Med Fac, Dept Cardiol Pneumol & Angiol, Cardiovasc Res Lab, Dusseldorf, Germany
[8] Univ Tsukuba, Environm Biol Sect, Fac Med, Ibaraki, Japan
[9] Queen Mary Univ London, Bart & London Sch Med, William Harvey Res Inst, Charterhouse Sq, London, England
[10] Sonoma State Univ, Dept Biol, Rohnert Pk, CA 94928 USA
[11] Tohoku Univ, Grad Sch Med, Dept Environm Med & Mol Toxicol, Sendai, Miyagi 9808575, Japan
关键词
cysteine persulfides; hydropersulfides; translational polysulfidation; CHEMICAL BIOLOGY; HYDROGEN-SULFIDE; ENZYME-ACTIVITIES; SULFUR; PERSULFIDES; CHEMISTRY; H2S; RADICALS; ACID; SELENOCYSTEINE;
D O I
10.1002/1873-3468.13090
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The chemical biology of thiols (RSH, e.g., cysteine and cysteine-containing proteins/peptides) has been a topic of extreme interest for many decades due to their reported roles in protein structure/folding, redox signaling, metal ligation, cellular protection, and enzymology. While many of the studies on thiol/sulfur biochemistry have focused on thiols, relatively ignored have been hydropersulfides (RSSH) and higher order polysulfur species (RSSnH, RSSnR, n > 1). Recent and provocative work has alluded to the prevalence and likely physiological importance of RSSH and related RSSnH. RSSH of cysteine (Cys-SSH) has been found to be prevalent in mammalian systems along with Cys-SSH-containing proteins. The RSSH functionality has not been examined to the extent of other biologically relevant sulfur derivatives (e.g., sulfenic acids, disulfides, etc.), whose roles in cell signaling are strongly indicated. The recent finding of Cys-SSH biosynthesis and translational incorporation into proteins is an unequivocal indication of its fundamental importance and necessitates a more profound look into the physiology of RSSH. In this Review, we discuss the currently reported chemical biology of RSSH (and related species) as a prelude to discussing their possible physiological roles.
引用
收藏
页码:2140 / 2152
页数:13
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