EGb-761 Attenuates the Anti-proliferative Activity of Fluoride via DDK1 in PC-12 Cells

被引：19

作者：

Zhang, Cai-Yi ^{[1
,2
,3
]}

Chen, Rui ^{[4
]}

Wang, Fen ^{[1
,2
,5
]}

Ren, Chao ^{[6
]}

Zhang, Peng ^{[3
]}

Li, Qian ^{[1
,2
]}

Li, Hui-Hua ^{[4
]}

Guo, Ke-Tai ^{[5
]}

Geng, De-Qin ^{[4
]}

Liu, Chun-feng ^{[1
,2
,5
]}

机构：

[1] Soochow Univ, Dept Neurol, Affiliated Hosp 2, Suzhou 215004, Peoples R China

[2] Soochow Univ, Suzhou Clin Res Ctr Neurol Dis, Affiliated Hosp 2, Suzhou 215004, Peoples R China

[3] Xuzhou Med Univ, Affiliated Xuzhou Oriental Hosp, 379 Tongshan Rd, Xuzhou 221000, Jiangsu, Peoples R China

[4] Xuzhou Med Univ, Dept Neurol, Affiliated Hosp, 99 Huaihai Rd, Xuzhou 221000, Jiangsu, Peoples R China

[5] Soochow Univ, Inst Neurosci, Suzhou 215123, Peoples R China

[6] Qingdao Univ, Dept Neurol, Affiliated Yantai Yuhuangding Hosp, Coll Med, Yantai 264000, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2017年 / 42卷 / 02期

基金：

中国国家自然科学基金;

关键词：

EGb-761; DKK1; Wnt singaling pathway; Proliferation; GINKGO-BILOBA EXTRACT; MESENCHYMAL STEM-CELLS; SIGNALING PATHWAY; WNT; PROLIFERATION; DIFFERENTIATION; DICKKOPF-1; ACTIVATION; CANCER;

D O I：

10.1007/s11064-016-2115-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

EGb-761 is commonly used as a treatment for ischemic brain injury, neurodegenerative diseases and some types of tumors (Christen and Maixent, in Cell Mol Biol 48(6):601-611, 2002). However, it is unclear whether EGb-761 affects the proliferation of cells exposed to fluoride. In this study, the proliferation and apoptosis of PC-12 cells exposed to fluoride were investigated and EGb-761 was used to protect PC-12 cells against the effects of fluoride. We found that the canonical Wnt signaling pathway was involved in the anti-proliferation of PC-12 cells exposed to fluoride. Furthermore, the results also showed that EGb-761 could attenuate the anti-proliferative activity of fluoride via DDK1 in PC-12 cells. This study may provide a new method for protecting against the inhibition of cell proliferation induced by fluoride.

引用

页码：606 / 614

页数：9

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