APOL1 Kidney Risk Alleles: Population Genetics and Disease Associations

被引：152

作者：

Limou, Sophie

Nelson, George W.

Kopp, Jeffrey B.

Winkler, Cheryl A.

机构：

[1] NCI, Basic Sci Program, Ctr Canc Res, NIH,Leidos Biomed Res Inc,Frederick Natl Lab, Ft Detrick, MD 21702 USA

[2] NIDDK, NIH, Bethesda, MD 20892 USA

来源：

ADVANCES IN CHRONIC KIDNEY DISEASE | 2014年 / 21卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Glomerular disease; Apolipoprotein L1; African admixture; APOL1; demographics; Chronic kidney disease; HIV-ASSOCIATED NEPHROPATHY; STAGE RENAL-DISEASE; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; HUMAN AFRICAN TRYPANOSOMIASIS; VARIANTS ASSOCIATE; NONDIABETIC NEPHROPATHY; HUMAN SERUM; AMERICANS; MYH9; PROGRESSION;

D O I：

10.1053/j.ackd.2014.06.005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

APOL1 kidney disease is a unique case in the field of the genetics of common disease: 2 variants (termed G1 and G2) with high population frequency have been repeatedly associated with nondiabetic CKDs, with very strong effect size (odds ratios 3-29) in populations of sub-Saharan African descent. This review provides an update on the spectrum of APOL1 kidney disease and on the worldwide distribution of these kidney risk variants. We also summarize the proper way to run a recessive analysis on joint and independent effects of APOL1 G1 and G2 kidney risk variants. (C) 2014 by the National Kidney Foundation, Inc. All rights reserved.

引用

页码：426 / 433

页数：8

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