Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity

被引：29

作者：

Bozzini, Tiziana ^{[1
]}

Botta, Giorgia ^{[1
]}

Delfino, Michela ^{[1
]}

Onofri, Silvano ^{[1
]}

Saladino, Raffaele ^{[1
]}

Amatore, Donatella ^{[2
,3
]}

Sgarbanti, Rossella ^{[4
,5
]}

Nencioni, Lucia ^{[2
]}

Palamara, Anna Teresa ^{[2
,4
]}

机构：

[1] Univ Tuscia, Dept Ecol & Biol, I-01100 Viterbo, Italy

[2] Univ Roma La Sapienza, Cenci Bolognetti Fdn, Inst Pasteur, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy

[3] Ceinge, Naples, Italy

[4] San Raffaele Pisana Sci Inst Res Hospitalizat & H, Rome, Italy

[5] Univ Telemat San Raffaele, Rome, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2013年 / 21卷 / 24期

关键词：

Catechols; Biocatalysis; Immobilized tyrosinase; Antiviral; Influenza A virus; A VIRUS-REPLICATION; ANTIOXIDANT ACTIVITY; OLIVE OIL; CONVENIENT SYNTHESIS; POLYPHENOL COMPOUNDS; MUSHROOM TYROSINASE; SELECTIVE SYNTHESIS; INFLUENZA; PROTEIN; HYDROXYTYROSOL;

D O I：

10.1016/j.bmc.2013.10.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：7699 / 7708

页数：10

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