Advances in the preparation and synthesis of heparin and related products

被引：63
作者：
Baytas, Sultan N. [1 ,2 ]
Linhardt, Robert J. [1 ,3 ,4 ]
机构：
[1] Rensselaer Polytech Inst, Ctr Biotechnol & Interdisciplinary Studies, Dept Chem & Chem Biol, Troy, NY 12180 USA
[2] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkey
[3] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA
[4] Rensselaer Polytech Inst, Dept Biol Sci, Ctr Biotechnol & Interdisciplinary Studies, Troy, NY 12180 USA
来源：
DRUG DISCOVERY TODAY | 2020年 / 25卷 / 12期
基金：
美国国家卫生研究院;
关键词：
Bioengineered heparin; Chemoenzymatic synthesis; Heparin; LMWH; Synthetic heparin;
D O I：
10.1016/j.drudis.2020.09.011
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Heparin is a naturally occurring glycosaminoglycan from livestock, principally porcine intestine, and is clinically used as an anticoagulant drug. A limitation to heparin production is that it depends on a single animal species and potential problems have been associated with animal-derived heparin. The contamination crisis in 2008 led to a search for new animal sources and the investigation of non-animal sources of heparin. Over the past 5 years, new animal sources, chemical, and chemoenzymatic methods have been introduced to prepare heparin based drugs. In this review, we describe advances in the preparation and synthesis of heparin and related products.
引用
收藏
页码：2095 / 2109
页数：15
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