Macrocyclic triamines as linkers in two-armed receptors for peptides

被引：8

作者：

Iorio, EJ ^{[1
]}

Still, WC ^{[1
]}

机构：

[1] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0960-894X(96)00500-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Commercially available triazamacrocycles have been substituted with trimesic acid/1,2-diamine cyclooligomers to create a new class of sequence-selective receptors for peptides. Screening of these compounds against a 3375-member library of N-acetyl tripeptides revealed novel peptide-binding properties. Copyright (C) 1996 Elsevier Science Ltd

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收藏

页码：2673 / 2676

页数：4

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共 12 条

[1] PEPTIDOSTEROIDAL RECEPTORS FOR OPIOID-PEPTIDES - SEQUENCE-SELECTIVE BINDING USING A SYNTHETIC RECEPTOR LIBRARY [J].

BOYCE, R ;

LI, G ;

NESTLER, HP ;

SUENAGA, T ;

STILL, WC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (17) :7955-7956

[2] SYNTHETIC IONOPHORES - ENCODED COMBINATORIAL LIBRARIES OF CYCLEN-BASED RECEPTORS FOR CU2+ AND CO2+ [J].

BURGER, MT ;

STILL, WC .

JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (23) :7382-7383

[3] Sequence-selective peptide binding with a peptido-A,B-trans-steroidal receptor selected from an encoded combinatorial receptor library [J].

Cheng, YA ;

Suenaga, T ;

Still, WC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (07) :1813-1814

[4] SYNTHETIC RECEPTORS BASED ON VINYLOGOUS SULFONYL PEPTIDES [J].

GENNARI, C ;

NESTLER, HP ;

SALOM, B ;

STILL, WC .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (16) :1765-1768

[5] A general synthesis of mono- and disubstituted 1,4,7-triazacyclononanes [J].

Kovacs, Z ;

Sherry, AD .

TETRAHEDRON LETTERS, 1995, 36 (51) :9269-9272

[6] PEPTIDOMIMETIC HOST THAT BINDS A PEPTIDE GUEST AFFORDING A BETA-SHEET STRUCTURE THAT SUBSEQUENTLY SELF-ASSEMBLES - A SIMPLE RECEPTOR MIMIC [J].

LABRENZ, SR ;

KELLY, JW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (05) :1655-1656

[7] Selective binding of the dipeptides L-Phe-D-Pro and D-Phe-L-Pro to beta-cyclodextrin [J].

Maletic, M ;

Wennemers, H ;

McDonald, DQ ;

Breslow, R ;

Still, WC .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (13-14) :1490-1492

[8] COMPLEX SYNTHETIC CHEMICAL LIBRARIES INDEXED WITH MOLECULAR TAGS [J].

OHLMEYER, MHJ ;

SWANSON, RN ;

DILLARD, LW ;

READER, JC ;

ASOULINE, G ;

KOBAYASHI, R ;

WIGLER, M ;

STILL, WC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) :10922-10926

[9] Sequence-selective receptors of peptides. A simple molecular design for construction of large combinatorial libraries of receptors [J].

Shao, YF ;

Still, WC .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (18) :6086-6087

[10] Discovery of sequence-selective peptide binding by synthetic receptors using encoded combinatorial libraries [J].

Still, WC .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :155-163