Waiting for ON: A major problem in patients with Parkinson disease and ON/OFF motor fluctuations

被引：28
作者：
Merims, D
Djaldetti, R
Melamed, E
机构：
[1] Rabin Med Ctr, Dept Neurol, IL-49100 Petah Tiqwa, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
来源：
CLINICAL NEUROPHARMACOLOGY | 2003年 / 26卷 / 04期
关键词：
Parkinson disease; fluctuations; delayed ON; time to ON;
D O I：
10.1097/00002826-200307000-00009
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors compared the two portions of the OFF period in patients with Parkinson disease and response fluctuations: time to ON (the latency from levodopa intake to turning ON) and wearing off (time from termination of the beneficial dose effect until the time when the next dose was taken). Time to ON was more than twice the duration of wearing off. Although underrecognized, time to ON is the major component of total daily OFF.
引用
收藏
页码：196 / 198
页数：3
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