Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project

被引：58

作者：

Dimakopoulou, Konstantina ^{[1
]}

Samoli, Evangelia ^{[1
]}

Beelen, Rob ^{[2
]}

Stafoggia, Massimo ^{[3
]}

Andersen, Zorana Jovanovic ^{[4
,5
]}

Hoffmann, Barbara ^{[6
]}

Fischer, Paul ^{[7
]}

Nieuwenhuijsen, Mark ^{[8
,9
]}

Vineis, Paolo ^{[10
]}

Xun, Wei ^{[10
]}

Hoek, Gerard ^{[2
]}

Raaschou-Nielsen, Ole ^{[4
]}

Oudin, Anna ^{[11
]}

Forsberg, Bertil ^{[11
]}

Modig, Lars ^{[11
]}

Jousilahti, Pekka ^{[12
]}

Lanki, Timo ^{[13
]}

Turunen, Anu ^{[13
]}

Oftedal, Bente ^{[14
]}

Nafstad, Per ^{[14
,15
]}

Schwarze, Per E. ^{[14
]}

Penell, Johanna ^{[16
]}

Fratiglioni, Laura ^{[17
]}

Andersson, Niklas ^{[16
,19
]}

Pedersen, Nancy ^{[18
]}

Korek, Michal ^{[16
]}

De Faire, Ulf ^{[16
]}

Eriksen, Kirsten Thorup ^{[4
]}

Tjonneland, Anne ^{[4
]}

Becker, Thomas ^{[20
]}

Wang, Meng ^{[2
]}

Bueno-de-Mesquita, Bas ^{[7
,10
,21
]}

Tsai, Ming-Yi ^{[22
,23
,24
]}

Eeftens, Marloes ^{[2
,22
,23
]}

Peeters, Petra H. ^{[10
,25
]}

Meliefste, Kees ^{[2
]}

Marcon, Alessandro ^{[26
]}

Kramer, Ursula ^{[6
]}

Kuhlbusch, Thomas A. J. ^{[27
]}

Vossoughi, Mohammad ^{[6
]}

Key, Timothy ^{[28
]}

de Hoogh, Kees ^{[10
]}

Hampel, Regina ^{[29
]}

Peters, Annette ^{[29
]}

Heinrich, Joachim ^{[30
]}

Weinmayr, Gudrun ^{[6
,31
]}

Concin, Hans ^{[32
]}

Nagel, Gabriele ^{[31
,32
]}

Ineichen, Alex ^{[22
,23
]}

Jacquemin, Benedicte ^{[8
,33
,35
]}

机构：

[1] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[2] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[3] Lazio Reg Hlth Serv, Dept Epidemiol, Lazio, Italy

[4] Danish Canc Soc Res Ctr, Copenhagen, Denmark

[5] Univ Copenhagen, Dept Publ Hlth, Ctr Epidemiol & Screening, Copenhagen, Denmark

[6] IUF Leibniz Res Inst Environm Med, Dusseldorf, Germany

[7] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[8] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[9] Consortium Biomed Res Epidemiol & Publ Hlth CIBER, Madrid, Spain

[10] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London, England

[11] Umea Univ, Dept Publ Hlth & Clin Med, Div Occupat & Environm Med, Umea, Sweden

[12] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[13] Natl Inst Hlth & Welf, Dept Environm Hlth, Kuopio, Finland

[14] Norwegian Inst Publ Hlth, Div Environm Med, Oslo, Norway

[15] Univ Oslo, Inst Hlth & Soc, Oslo, Norway

[16] Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden

[17] Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

[18] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[19] Stockholm Cty Council, Ctr Occupat & Environm Med, Stockholm, Sweden

[20] Aarhus Univ, Dept Environm Sci, Roskilde, Denmark

[21] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[22] Swiss Trop & Publ Hlth Inst, Basel, Switzerland

[23] Univ Basel, Basel, Switzerland

[24] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA

[25] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[26] Univ Verona, Dept Publ Hlth & Community Med, Unit Epidemiol & Med Stat, I-37100 Verona, Italy

[27] Inst Energy & Environm Technol eV, Air Qual & Sustainable Nanotechnol, Duisburg, Germany

[28] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[29] German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Epidemiol 2, Neuherberg, Germany

[30] German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Epidemiol 1, Neuherberg, Germany

[31] Univ Ulm, Inst Epidemiol & Med Biometry, D-89069 Ulm, Germany

[32] Agcy Prevent & Social Med, Bregenz, Austria

[33] Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Resp & Environm Epidemiol Team, Villejuif, France

[34] Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Nutr Hormones & Womens Hlth Team, Villejuif, France

[35] Univ Paris Sud, Villejuif, France

[36] French Inst Publ Hlth Surveillance, InVS, St Maurice, France

[37] IGR, Villejuif, France

[38] Iuman Genet Fdn, Turin, Italy

[39] Univ Turin, Unit Canc Epidemiol, AO Cilia Salute & Sci, Turin, Italy

[40] Ctr Canc Prevent, Turin, Italy

[41] Hellenic Hlth Fdn, Athens, Greece

[42] Kings Coll London, Environm Res Grp, London WC2R 2LS, England

[43] Kings Coll London, Dept Primary Care & Publ Hlth Sci, London WC2R 2LS, England

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2014年 / 189卷 / 06期

基金：

美国国家卫生研究院; 芬兰科学院; 瑞典研究理事会;

关键词：

environmental exposure; public health; metaanalysis; USE REGRESSION-MODELS; LONG-TERM EXPOSURE; EXTENDED FOLLOW-UP; PARTICULATE MATTER; PM2.5; ABSORBENCY; NITROGEN-DIOXIDE; CANCER INCIDENCE; CITIES; NO2; AREAS;

D O I：

10.1164/rccm.201310-1777OC

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant respiratory mortality are less studied, and the data reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements and Main Results: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within, the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts, there was no-association between air pollution exposure and nonmalignant respiratory mortality.

引用

页码：684 / 696

页数：13

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